1289646-93-0 Usage
Uses
Used in Pharmaceutical Synthesis:
6-Isoquinolinecarboxylic acid, 5,7-dichloro-1,2,3,4-tetrahydro-, hydrochloride (1:1) is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure and properties make it a valuable building block for the development of new drugs with potential therapeutic applications.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, this quinoline derivative is utilized for the design and synthesis of novel bioactive molecules. Its chemical versatility allows for the creation of diverse chemical entities with potential applications in treating various diseases and medical conditions.
Used in Drug Discovery:
6-Isoquinolinecarboxylic acid, 5,7-dichloro-1,2,3,4-tetrahydro-, hydrochloride (1:1) plays a crucial role in drug discovery processes. It serves as a starting material or a scaffold for the development of new drug candidates, which can be further optimized for improved potency, selectivity, and pharmacokinetic properties.
Used in Chemical Synthesis:
Apart from its applications in pharmaceuticals and medicine, this compound also finds use in various chemical synthesis processes. Its unique structure and reactivity make it a valuable component in the synthesis of other organic compounds and materials.
Check Digit Verification of cas no
The CAS Registry Mumber 1289646-93-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,8,9,6,4 and 6 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1289646-93:
(9*1)+(8*2)+(7*8)+(6*9)+(5*6)+(4*4)+(3*6)+(2*9)+(1*3)=220
220 % 10 = 0
So 1289646-93-0 is a valid CAS Registry Number.
1289646-93-0Relevant articles and documents
Scalable Process for Making 5,7-Dichlorotetrahydroisoquinoline-6-carboxylic Acid Using Methylene as the Protecting Group
Xu, Wanbin,Gong, Xudong,Odilov, Abdullajon,Hu, Tianwen,Jiang, Xiangrui,Zhu, Fuqiang,Guo, Shuang,Jiang, Dehui,Wu, Mingjun,Shen, Jingshan
, p. 2447 - 2452 (2021/11/13)
The development of an industrially scalable synthetic route for 5,7-dichlorotetrahydroisoquinoline-6-carboxylic acid (1), a key starting material for lifitegrast, is described. This route includes the following features: (1) tetrahydroisoquinoline19was pr
3,5-dichloro-4-bromoisoquinoline derivative, and preparation method and application thereof
-
, (2019/10/04)
The invention specifically relates to a novel compound, i.e., a 3,5-dichloro-4-bromoisoquinoline derivative, and a preparation method and application thereof, belonging to the technical field of pharmaceutical synthesis. 3,5-dichloro-4-bromoisoquinoline and the derivative thereof are obtained by ring closure of 3,5-dichloro-4-bromobenzene haloethylamine through a Friedel-Crafts alkylation reaction. The 3,5-dichloro-4-bromoisoquinoline and the derivative can be used for synthesizing the important intermediate 3,5-dichloro-4-carboxylisoquinoline of Lifitegrast. According to a technical scheme in the invention, low-cost and well-supplied 2,6-dichloroaniline is used as a starting material; and the preparation method comprises a plurality steps of reactions with mild conditions, mature operation and yield of 85% or more, and each step of reaction has passed pilot-scale test, so the feasibility of industrial conversion of the method is very high and overall production cost can be greatly reduced.
