129473-55-8

Basic information

• Product Name: (S)-2-amino-3-methyl-N-phenylbutanamide
• Synonyms: (S)-2-amino-3-methyl-N-phenylbutanamide
• CAS NO: 129473-55-8
• Molecular Weight: 192.261
• Mol File: 129473-55-8.mol
• Article Data: 20

Chemical Properties

• CAS DataBase Reference: (S)-2-amino-3-methyl-N-phenylbutanamide(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-amino-3-methyl-N-phenylbutanamide(129473-55-8)
• EPA Substance Registry System: (S)-2-amino-3-methyl-N-phenylbutanamide(129473-55-8)

Safety Data

• Hazardous Substances Data: 129473-55-8(Hazardous Substances Data)

Usage

Description

(S)-2-amino-3-methyl-N-phenylbutanamide, with the molecular formula C12H17NO, is an amide derivative of phenylbutanamide. It is a chiral molecule, existing in two enantiomeric forms, with the (S)-enantiomer being the more biologically active one. (S)-2-amino-3-methyl-N-phenylbutanamide has been investigated for its potential pharmaceutical properties, such as acting as a GABA-A receptor agonist and showing promise as a protective agent against neurodegeneration. Further research is necessary to comprehend its full biological activity and possible applications in the medical field.

Uses

Used in Pharmaceutical Industry:
(S)-2-amino-3-methyl-N-phenylbutanamide is used as a GABA-A receptor agonist for its potential role in treating neurological disorders and conditions related to the central nervous system. Its agonistic activity on GABA-A receptors may contribute to its therapeutic effects.
Used in Neuroprotective Applications:
(S)-2-amino-3-methyl-N-phenylbutanamide is used as a protective agent against neurodegeneration due to its potential to shield neurons from damage and promote neuronal health. This application could be particularly relevant in the development of treatments for neurodegenerative diseases such as Alzheimer's, Parkinson's, and other conditions involving neuronal loss.

Upstream product

• 108-86-1 bromobenzene 
• 4540-60-7 L-valinamide 
• 591-50-4 iodobenzene 
• 1149-26-4 (S)-N-(benzyloxycarbonyl)valine 
• 62-53-3 aniline 
• 13734-41-3 t-Boc-L-valine 
• 6306-54-3 N-phthaloyl L-valine 
• 5511-73-9 N-phthalimide l-valinyl chloride 
• 99529-85-8 C₁₉H₁₈N₂O₃ 
• 23601-86-7 (RS)-valine anilide 
• 126787-26-6 ((S)-2-methyl-1-phenylcarbamoylpropyl)carbamic acid tert-butyl ester 
• 72-18-4 L-valine 

Downstream Products

• 1000072-70-7 (2S)-3-methyl-N-phenyl-2-((3-phenylaziridin-2-yl)methylamino)butanamide 
• 1000072-73-0 (S)-3-methyl-2-(((2S,3S)-3-methylaziridin-2-yl)methylamino)-N-phenylbutanamide 
• 1000072-74-1 (S)-2-((R)-aziridin-2-ylmethylamino)-3-methyl-N-phenylbutanamide 
• 1000072-71-8 (S)-2-(((2R,3S)-3-((tert-butyldimethylsilyloxy)methyl)aziridin-2-yl)methylamino)-3-methyl-N-phenylbutanamide 
• 908253-01-0 (S)-N¹-phenyl-3-methylbutane-1,2-diamine 
• 1308326-92-2 C₁₆H₂₅N₃O₂ 
• 29618-28-8 (S)-N-benzoyl-valine anilide 
• 1187975-87-6 5-oxo-2-phenethyltetrahydrofuran-2-carboxylic acid ((S)-2-methyl-1-phenylcarbamoylpropyl)amide 
• 138522-39-1 (4S)-4-(1-methylethyl)-1-phenyl-2-imidazolidinone 
• 1375257-35-4 (S)-3-[(S)-3-hydroxy-3-phenylpropanoyl]-4-isopropyl-1-phenylimidazolidin-2-one 
• 1375257-27-4 N-acetyl-(S)-4-isopropyl-1-phenylimidazolidine-2-one 

Relevant articles and documents

A study of the various factors that affect the properties of molecularly imprinted polymers

We evaluated the adsorbability and selectivity of (S)-valine anilide imprinted molecularly imprinted polymer (MIP) using a batch procedure that is both independent and precise. This study revealed important information about the relationship between the performance of MIPs and experimental factors such as the components of MIP synthesis and a reaction solvent. Herein, we also describe the problems associated with the preparation of a non-imprinted polymer, which is often used to evaluate the effect of a template molecule, and we propose a new type of reference polymer, blank polymer .

Linker, Antibody-Drug Conjugate Including Same and Use Thereof

Provided are a linker represented by Formula I or I′, an antibody-drug conjugate containing the same, and use of thereof, a pharmaceutical composition comprising the antibody-drug conjugate, and use of the antibody-drug conjugate for treating and/or preventing a disease.

Design, synthesis, and insecticidal activities of novel diamide derivatives with alpha-amino acid subunits

A series of diamide derivatives containing α-amino acids were designed and synthesized. These compounds were evaluated for their insecticidal activities against Plutella xylostella, Mythimna separate, Myzus persicae, and Tetranychus cinnabarinus. Most of the title compounds containing an l-phenylglycine skeleton were endowed with good activities at the concentration of 500 mg·L?1. Compounds (R)-A6 showed a potential value for further optimization as an insecticidal lead with the LC50 value of 86.8 mg·L?1.

Synthetic process of chiral N-aromatic amino acid amide

Chiral N-aromatic amino acid amide is a core structure fragment of drugs and an intermediate of the drugs. Only if the chiral structure of the product is not required by special raw materials such aryl halide activated by functional groups of nitryl and t