5511-73-9

Basic information

• Product Name: N-phthalimide l-valinyl chloride
• Synonyms: N-phthalimide l-valinyl chloride
• CAS NO: 5511-73-9
• Molecular Weight: 265.696
• Mol File: 5511-73-9.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: N-phthalimide l-valinyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: N-phthalimide l-valinyl chloride(5511-73-9)
• EPA Substance Registry System: N-phthalimide l-valinyl chloride(5511-73-9)

Safety Data

• Hazardous Substances Data: 5511-73-9(Hazardous Substances Data)

Upstream product

• 85-44-9 phthalic anhydride 
• 72-18-4 L-valine 

Downstream Products

• 908253-01-0 (S)-N¹-phenyl-3-methylbutane-1,2-diamine 
• 882528-81-6 Val-NH-iPr 
• 870533-29-2 (S)-2-amino-N-(4-fluorophenyl)-3-methylbutanamide 
• 1309478-56-5 C₁₁H₁₇FN₂ 
• 3057-81-6 (S)-2-amino-N-tert-butyl-3-methylbutanamide 
• 129473-55-8 (S)-2-amino-3-methyl-N-phenylbutanamide 
• 99529-85-8 C₁₉H₁₈N₂O₃ 
• 1309478-53-2 C₁₉H₁₇FN₂O₃ 
• 1416453-22-9 (2R)-2-methyl-1-[N-phthaloyl-(S)-valyl]-1,2,3,4-tetratetrahydroquinoline 
• 1416453-21-8 (2S)-2-methyl-1-[N-phthaloyl-(S)-valyl]-1,2,3,4-tetrahydroquinoline 
• 200125-70-8 (S)-2-methyl-1,2,3,4-tetrahydroquinoline 
• 1780-19-4 (R)-1,2,3,4-tetrahydroquinaldine 

Relevant articles and documents

Chiral Pool-Based Synthesis of Naphtho-Fused Isocoumarins

A variety of chiral derivatives of benzo[d]naphtho[1,2-b]pyran-6-one were prepared in a single step by Et3N-mediated condensation of homophthalic anhydride with different derivatives of (S)-amino acid chlorides at -5 °C by employing a chiral pool methodology. Chirality 27:951-957, 2015.

AMINO ACID DERIVATIVES FOR THE TREATMENT OF INFLAMMATORY DISEASES

The present disclosure provides certain amino acid derivatives that inhibit NF-kB activation and are therefore useful for the treatment of inflammatory diseases. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.

1,2-Hydride Migration in Dialkyl α-Diazophosphonates Catalyzed by [Cu(MeCN)4]PF6: A Novel Approach to β-Amino (E)-Enylphosphonates

The regiospecific and stereoselective 1,2-migration reaction of dialkyl α-diazophosphonates for the synthesis of β-amino (E)-enylphosphonates is developed utilizing tetrakis(acetonitrile)copper(I) hexafluorophosphate [Cu(MeCN)4PF6] as the catalyst and N,N-dimethylformamide as an additive. A possible mechanism for the 1,2-migration reaction involving a metal carbene is presented. An investigation on the E/Z isomer selectivity of this process demonstrates that steric factors play an important role on the outcome. This process provides a straightforward access to β-amino (E)-enylphosphonates in moderate to good yields.

Trifluoroborane-catalyzed C-H functionalization/S-H insertion reaction: Construction of N,S-acetal quaternary centers

Abstract The trifluoroborane-catalyzed C-H functionalization/S-H insertion reaction of α-diazophosphonates with thiols has been developed. A plausible reaction mechanism has been proposed to understand the combined reaction. This process provides straightforward access to N,S-acetals containing quaternary centers in moderate to good yields and chemoselectivity.