1296194-42-7Relevant articles and documents
Atropisomeric and conformational properties of 6N-benzoyl-and 6N-p-tosyl-1,6-benzodiazocines: Comparison with those of 1,5-benzodiazepines
Tabata, Hidetsugu,Murai, Kazuya,Funaki, Kaoru,Takemae, Chihiro,Tasaka, Tomohiko,Oshitari, Tetsuta,Takahashi, Hideyo,Natsugari, Hideaki
, p. 566 - 581 (2019/08/01)
The atropisomeric and conformational properties of the eight-membered 1,6-benzodiazocines (2) with 6N-benzoyl (A) and 6N-p-tosyl (B) groups were examined by comparing them with those of the seven-membered 1,5-benzodiazepine congeners (1) (A, B). The confo
Atropisomerism in the vaptan class of vasopressin receptor ligands: The active conformation recognized by the receptor
Tabata, Hidetsugu,Nakagomi, Jun,Morizono, Daisuke,Oshitari, Tetsuta,Takahashi, Hideyo,Natsugari, Hideaki
, p. 3075 - 3079 (2011/05/05)
(Chemical Equation Presented) Latent chirality: Atropisomerism in the vaptan class of vasopressin receptor ligands with N-benzoyl benzo-fused seven-membered-ring nitrogen heterocycles was investigated by freezing the axis by ortho substitution. The aS/aR atropisomers caused by the Ar-N(=CO) axis were separated to reveal that the vasopressin receptor recognizes the cis,aS conformation (see picture; R=CH3, X= -CO-, Y=H) when it binds to the ligand.