129801-99-6Relevant articles and documents
Oligodeoxynucleotides with extended zwitter-ionic internucleotide linkage
Kochetkova, Svetlana V,Timofeev, Edward N,Korobeinikova, Ekaterina A,Kolganova, Natalia A,Florentiev, Vladimir L
, p. 10287 - 10292 (2001)
Two non-natural nucleoside analogues, N-(2-hydroxyethyl)-2′,5′-dideoxy-5′-aminothymidine (dTNH) and N-(2-hydroxyethyl)-N-methyl-2′,5′-dideoxy-5′-aminothymidine (dTNMe), have been prepared and used in the synthesis of oligodeoxythymidilates and mixed-sequence oligodeoxynucleotides, modified at internucleotide linkages. Both modified oligodeoxythymidilates and mixed-sequence oligodeoxynucleotides have been shown to form zwitter-ionic phosphate-amine pairs as evidenced by their decreased electrophoretic mobility in denaturing polyacrylamide gel.
Introduction of an alkyl group into the sugar portion of uracilnucleosides by the use of Gilman reagents
Hayakawa,Ashizawa,Tanaka,Miyasaka
, p. 355 - 360 (2007/10/02)
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