129835-17-2

Basic information

• Product Name: 9-[3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-arabinofuranosyl]guanine
• Synonyms: 9-[3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-arabinofuranosyl]guanine
• CAS NO: 129835-17-2
• Molecular Weight: 525.753
• Mol File: 129835-17-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 9-[3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-arabinofuranosyl]guanine(CAS DataBase Reference)
• NIST Chemistry Reference: 9-[3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-arabinofuranosyl]guanine(129835-17-2)
• EPA Substance Registry System: 9-[3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-arabinofuranosyl]guanine(129835-17-2)

Safety Data

• Hazardous Substances Data: 129835-17-2(Hazardous Substances Data)

Upstream product

• 38819-10-2 9-β-D-arabinofuranosylguanine 
• 69304-37-6 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane 

Downstream Products

• 38819-10-2 9-β-D-arabinofuranosylguanine 
• 1620667-59-5 2'-chloro-2'-deoxyguanosine-5'-monophosphate 
• 73-40-5 2-amino-1,9-dihydro-6H-purin-6-one 
• 92544-22-4 2-methylene-3(2H)-furanone 
• 144089-96-3 N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-fluoro-4-hydroxytetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide 
• 78842-13-4 2'-deoxy-2'-fluoroguanosine 
• 80681-25-0 2’-fluoro-N2-isobutyryl-2’-deoxyguanosine 
• 603112-57-8 3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-2'-deoxy-(2-nitrophenyldithio)guanosine 
• 603112-58-9 2'-deoxy-2'-(2-nitrophenyldithio)guanosine 
• 908371-60-8 N²-acetyl-9-{2'-O-[(trifluoromethyl)sulfonyl]-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-arabinofuranosyl}-O⁶-[2-(4-nitrophenyl)ethyl]guanine 
• 908371-53-9 N²-acetyl-9-[2'-O-acetyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-arabinofuranosyl]-O⁶-[2-(4-nitrophenyl)ethyl]guanine 
• 908371-59-5 N²-acetyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-O⁶-[2-(4-nitrophenyl)ethyl]-2'-deoxy-2'-methylselenoguanosine 
• 908371-55-1 N²-acetyl-9-[3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-arabinofuranosyl]-O⁶-[2-(4-nitrophenyl)ethyl]guanine 
• 908371-57-3 N²-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-2'-methylselenoguanosine 

Relevant articles and documents

Synthesis and crystal structure of 2'-Se-modified guanosine containing DNA

(Chemical Equation Presented) Selenium modification of nucleic acids is of great importance in X-ray crystal structure determination and functional study of nucleic acids. Herein, we describe a convenient synthesis of a new building block, the 2′-SeMe-modified guanosine (GSe) phosphoramidite, and report the first incorporation of the 2′-Se-G moiety into DNA. The X-ray crystal structure of the 2′-Se-modified octamer DNA (5′-GTGSeTACAC-3′) was determined at a resolution of 1.20 A.We also found that the 2′-Se modification points to the minor groove and that the modified and native structures are virtually identical. Furthermore, we observed that the 2′-Se-G modification can significantly facilitate the crystal growth with respect to the corresponding native DNA.