69304-37-6 Usage
Chemical Properties
Colorless liquid
Physical properties
bp 70°C/0.5 mmHg; d 0.986 g cm?3.
Uses
Different sources of media describe the Uses of 69304-37-6 differently. You can refer to the following data:
1. 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane is used in the analysis of Watson-Crick and Hoogstein base pairing in nucleotides. Also used in the formation of ribavirin chemical delivery systems.
2. 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane can be used as simultaneous protection of the 3'- and 5'-hydroxyl functions of
furanose nucleosides;protecting group for carbohydrates;3,4
protecting group reagent for open-chain polyhydroxy compounds;
preparation of cyclic bridged peptides.
The reagent
design was based upon the fact that triisopropylsilyl chloride
reacts 1000 times faster with primary alcohols than secondary
alcohols. Thus in the case of 3',5'-dihydroxy nucleosides the
reagent initially silylates at the 5'-position. This is then followed
by intramolecular reaction with the secondary alcohol at the
3'-position to give the doubly protected derivative (eq 1).
3. 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane is a silylating reagent used for simultaneous protection of 3'- and 5'-hydroxy functions of ribonucleosides. It is used in the analysis of Watson-Crick and Hoogstein base pairing in nucleotides. It is also employed in the formation of ribavirin chemical delivery systems. Further, it serves as a protecting group reagent for open-chain polyhydroxy compounds. In addition to this, it is involved in the preparation of cyclic bridged peptides.
Preparation
can be prepared starting from trichlorosilane
by treatment with i-PrMgCl, H2O, and acetyl chloride.
Alternatively, it can be prepared by the reaction of 1,1,3,3-
tetraisopropyldisiloxane with CCl4 in the presence of catalytic
PdCl2.This method is also suitable for its in situ preparation.
Check Digit Verification of cas no
The CAS Registry Mumber 69304-37-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,9,3,0 and 4 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 69304-37:
(7*6)+(6*9)+(5*3)+(4*0)+(3*4)+(2*3)+(1*7)=136
136 % 10 = 6
So 69304-37-6 is a valid CAS Registry Number.
InChI:InChI=1/C12H28Cl2OSi2/c1-9(2)16(13,10(3)4)15-17(14,11(5)6)12(7)8/h9-12H,1-8H3
69304-37-6Relevant articles and documents
Building blocks for oligomeric siloxanes –selective chlorination of hydrido-siloxanes
Hafner, Thomas,Torvisco, Ana,Uhlig, Frank
supporting information, p. 1 - 4 (2018/09/11)
A new method was developed to achieve highly selective monochlorination of α,ω-dihydridosiloxanes, ((H)Me2SiO-(SiMe2O)n-SiMe2(H), n = 0–2; (H)R2Si–O-SiR2(H); R = Me, iPr, Ph; 3,5-dihydridooctamethyltetrasiloxane, Me3SiO-(Si(H)MeO)2–SiMe3) with trichloroisocyanuric acid (TCCA). The dependence of the selectivity of the monochlorination on the siloxane chain length is also discussed.
Preparation of 1,1,3,3-tetraisopropyl-1,3-dichlorodisiloxane and triisopropylchlorosilane
Chawla, Ram,Larson, Gerald L.
, p. 3499 - 3501 (2007/10/03)
A facile, hydrochloric acid-free chlorination of silanes was developed. This allows for the elimination of siloxane bond cleavage and chlorination of carbon-hydrogen bonds during the chlorination of the Si-H bond.
A VERY EFFICIENT AND STRAIGHFORWARD SYNTHESIS OF 1,3-DICHLORO 1,1,3,3-TETRAISOPROPYLDISILOXANE
Zhang, H. X.,Guibe, F.,Balavoine, G.
, p. 1299 - 1308 (2007/10/02)
In the presence of catalytic amount of palladium on charcoal, acetyl chloride smoothly chlorinates TIDPSiH2 at room temperature to give TIDPSiCl2 in high yield and in a high state of purity.
