129872-81-7

Basic information

• Product Name: 2,4-Dichloro-5-methyl-5H-pyrrolo[3,2-d]pyrimidine
• Synonyms: 2,4-Dichloro-5-methyl-5H-pyrrolo[3,2-d]pyrimidine;5H-Pyrrolo[3,2-d]pyrimidine,2,4-dichloro-5-methyl-
• CAS NO: 129872-81-7
• Molecular Formula: C₇H₅Cl₂N₃
• Molecular Weight: 202.044
• Mol File: 129872-81-7.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• Density: 1.6g/cm³
• Refractive Index: 1.7
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2,4-Dichloro-5-methyl-5H-pyrrolo[3,2-d]pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Dichloro-5-methyl-5H-pyrrolo[3,2-d]pyrimidine(129872-81-7)
• EPA Substance Registry System: 2,4-Dichloro-5-methyl-5H-pyrrolo[3,2-d]pyrimidine(129872-81-7)

Safety Data

• Hazardous Substances Data: 129872-81-7(Hazardous Substances Data)

Usage

General Description

2,4-Dichloro-5-methyl-5H-pyrrolo[3,2-d]pyrimidine is a chemical compound with the molecular formula C7H5Cl2N3. It is a pyrrolopyrimidine derivative, which has potential applications in the field of medicinal chemistry and pharmaceuticals. 2,4-Dichloro-5-methyl-5H-pyrrolo[3,2-d]pyrimidine has been studied for its anti-proliferative and anti-cancer properties, and it has shown promising results in inhibiting the growth of certain types of cancer cells. Additionally, it has also been investigated for its potential use in the development of new drugs for the treatment of parasitic infections such as malaria. Its unique structure and pharmacological properties make it an interesting candidate for further research and development in the field of drug discovery.

InChI:InChI=1/C7H5Cl2N3/c1-12-3-2-4-5(12)6(8)11-7(9)10-4/h2-3H,1H3

Upstream product

• 63200-54-4 2,4-dichloro-5H-pyrrolo[3,2-d]pyrimidine 
• 74-88-4 methyl iodide 
• 66-27-3 Methyl methanesulfonate 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 129872-84-0 2-chloro-5-methyl-5H-pyrrolo<3,2-d>pyrimidin-4(3H)-one 
• 914497-02-2 2-chloro-4-(mesityloxy)-5-methyl-5H-pyrrolo[3,2-d]pyrimidine 
• 914497-03-3 4-(2-chloro-5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yloxy)-3,5-dimethylbenzonitrile 
• 1375301-63-5 4-(2-chloro-5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yl)morpholine 
• 1451913-19-1 (S)-1-ethyl-3-(4-(5-methyl-4-(3-methylmorpholino)-5H-pyrrolo[3,2-d]pyrimidin-2-yl)phenyl)urea 
• 1451913-22-6 (S)-1-ethyl-3-(4-(4-(3-ethylmorpholino)-5-methyl-5H-pyrrolo[3,2-d]pyrimidin-2-yl)phenyl)urea 
• 1620147-20-7 N-(2,6-dimethylphenyl)-4-((5-methyl-4-(4-(trifluoromethoxy)phenyl)-5H-pyrrolo[3,2-d]pyrimidin-2-yl)amino)benzamide 
• 1620147-21-8 4-((5-methyl-4-(4-(trifluoromethoxy)phenyl)-5H-pyrrolo[3,2-d]pyrimidin-2-yl)amino)-N-(2-methyl-5-((4-methylpiperazin-1-yl)methyl)phenyl)benzamide 
• 1620147-19-4 2-chloro-5-methyl-4-(4-(trifluoromethoxy)phenyl)-5H-pyrrolo[3,2-d]pyrimidine 

Relevant articles and documents

PYRIMIDINE PYRROLE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND USES THEREOF

The present invention relates to a compound of formula I, a stereoisomer, a prodrug, a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable solvate thereof, and a process for preparing the same, a pharmaceutical composition comprising the same, and use of the compound in the preparation of medicine preventing and treating tumors, wherein the substituents are as defined in the specification.

Pyrrolo pyrimidine derivate and application thereof

The invention belongs to the field of medicinal chemistry, and specifically relates to a pyrrolo pyrimidine derivate. The structure of the pyrrolo pyrimidine derivate is shown as formula (I), wherein X and Y independently represent N, O and S or SO; R1 is

FUSED BICYCLIC HETEROAROMATIC DERIVATIVES AS KINASE INHIBITORS

A series of fused bicyclic heteroaromatic derivatives of formula (IA) or (IB), as defined herein, being selective inhibitors of phosphatidylinositol-4-kinase IIIβ (PI4KIIIβ) activity, are beneficial in the treatment and/or prevention of various human ailm