1451913-22-6

Basic information

• Product Name: (S)-1-ethyl-3-(4-(4-(3-ethylmorpholino)-5-methyl-5H-pyrrolo[3,2-d]pyrimidin-2-yl)phenyl)urea
• CAS NO: 1451913-22-6
• Molecular Weight: 408.503
• Mol File: 1451913-22-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-1-ethyl-3-(4-(4-(3-ethylmorpholino)-5-methyl-5H-pyrrolo[3,2-d]pyrimidin-2-yl)phenyl)urea(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-ethyl-3-(4-(4-(3-ethylmorpholino)-5-methyl-5H-pyrrolo[3,2-d]pyrimidin-2-yl)phenyl)urea(1451913-22-6)
• EPA Substance Registry System: (S)-1-ethyl-3-(4-(4-(3-ethylmorpholino)-5-methyl-5H-pyrrolo[3,2-d]pyrimidin-2-yl)phenyl)urea(1451913-22-6)

Safety Data

• Hazardous Substances Data: 1451913-22-6(Hazardous Substances Data)

Upstream product

• 748117-01-3 (S)-3-ethylmorpholine 
• 129872-81-7 2,4-dichloro-5-methyl-5H-pyrrolo<3,2-d>pyrimidine 

Relevant articles and documents

A hit to lead discovery of novel N-methylated imidazolo-, pyrrolo-, and pyrazolo-pyrimidines as potent and selective mTOR inhibitors

A series of N-7-methyl-imidazolopyrimidine inhibitors of the mTOR kinase have been designed and prepared, based on the hypothesis that the N-7-methyl substituent on imidazolopyrimidine would impart selectivity for mTOR over the related PI3Kα and δ kinases. The corresponding N-Me substituted pyrrolo[3,2-d]pyrimidines and pyrazolo[4,3-d]pyrimidines also show potent mTOR inhibition with selectivity toward both PI3α and δ kinases. The most potent compound synthesized is pyrazolo[4,3-d]pyrimidine 21c. Compound 21c shows a Ki of 2 nM against mTOR inhibition, remarkable selectivity (>2900×) over PI3 kinases, and excellent potency in cell-based assays.