1301146-84-8Relevant articles and documents
Ligand Dependent Switch from RXR Homo- to RXR-NURR1 Heterodimerization
Scheepstra, Marcel,Andrei, Sebastian A.,De Vries, Rens M. J. M.,Meijer, Femke A.,Ma, Jian-Nong,Burstein, Ethan S.,Olsson, Roger,Ottmann, Christian,Milroy, Lech-Gustav,Brunsveld, Luc
, p. 2065 - 2077 (2017)
Retinoid X receptors (RXRs) play key roles in many physiological processes in both the periphery and central nervous system. In addition, RXRs form heterodimers with other nuclear receptors to exert their physiological effects. The nuclear receptor relate
TRICYCLIC PIPERIDINE COMPOUNDS
-
Page/Page column 129, (2015/06/08)
The present invention relates to compounds of the formula (I), wherein R, R1a, R1b, R2, R3, and X are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), to methods for the preparation of such compounds of formula (I), and especially to their use as TPH modulators.