130496-57-0

Basic information

• Product Name: (5R^*,6R^*)-5-Methoxy-2,2-dimethyl-6-phenyl-3-heptanone
• CAS NO: 130496-57-0
• Molecular Weight: 248.365
• Mol File: 130496-57-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (5R^*,6R^*)-5-Methoxy-2,2-dimethyl-6-phenyl-3-heptanone(CAS DataBase Reference)
• NIST Chemistry Reference: (5R^*,6R^*)-5-Methoxy-2,2-dimethyl-6-phenyl-3-heptanone(130496-57-0)
• EPA Substance Registry System: (5R^*,6R^*)-5-Methoxy-2,2-dimethyl-6-phenyl-3-heptanone(130496-57-0)

Safety Data

• Hazardous Substances Data: 130496-57-0(Hazardous Substances Data)

Upstream product

• 90-87-9 2-phenylpropionaldehyde dimethyl acetal 
• 17510-46-2 3,3-dimethyl-2-(trimethylsilyl)oxy-1-butene 
• 107369-61-9 (5S,6S)-2,2-Dimethyl-6-phenyl-heptane-3,5-diol 
• 74-88-4 methyl iodide 
• 84850-32-8 (5SR,6RS)-5-hydroxy-2,2-dimethyl-6-phenylheptan-3-one 

Relevant articles and documents

FeCl3·6H2O-catalyzed mukaiyama-aldol type reactions of enolizable aldehydes and acetals

Mukaiyama-aldol type reactions of acetals derived from enolizable aldehydes with FeCl3·6H2O, an eco-friendly, low-cost, and stable catalyst, lead to β-methoxycarbonyl compounds with nearly quantitative yields. The methodology is extended to the parent aldehydes as starting materials, leading to the corresponding aldols with lower yields, but efficiently. Different alkyl and aryl substituted acetals and aldehydes have been tested in the reaction with linear and cyclic silyl enol ethers. Reactions are carried out in an open air atmosphere, and additives are not required. Acetals can be considered activating groups of the carbonyl moiety rather than a protecting group in this type of FeCl3·6H2O-catalyzed condensation.