1305196-61-5Relevant articles and documents
Azaindoles as potent CRTH2 receptor antagonists
Simard, Daniel,Leblanc, Yves,Berthelette, Carl,Zaghdane, M. Helmi,Molinaro, Carmela,Wang, Zhaoyin,Gallant, Michel,Lau, Stephen,Thao, Trinh,Hamel, Martine,Stocco, Rino,Sawyer, Nicole,Sillaots, Susan,Gervais, Francois,Houle, Robert,Levesque, Jean-Franois
scheme or table, p. 841 - 845 (2011/03/18)
A new class of 7-azaindole analogs of MK-7246 as potent and selective CRTH2 antagonists is reported. The SAR leading to the identification of the optimal azaindole regioisomer as well as the pharmacokinetics and off-target activities of the most potent antagonists are disclosed.
