93748-19-7

Basic information

• Product Name: 2-(4-Fluorophenyl)-2-methylpropanoic acid
• Synonyms: 2-(4-Fluorophenyl)-2-methylpropanoic acid;2-(4-Fluorophenyl)-2-methylpropionic acid
• CAS NO: 93748-19-7
• Molecular Formula: C₁₀H₁₁FO₂
• Molecular Weight: 182
• Mol File: 93748-19-7.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 268.8±15.0 °C(Predicted)
• Appearance: /
• Density: 1.175±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 4.36±0.10(Predicted)
• CAS DataBase Reference: 2-(4-Fluorophenyl)-2-methylpropanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Fluorophenyl)-2-methylpropanoic acid(93748-19-7)
• EPA Substance Registry System: 2-(4-Fluorophenyl)-2-methylpropanoic acid(93748-19-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 93748-19-7(Hazardous Substances Data)

Usage

General Description

2-(4-Fluorophenyl)-2-methylpropanoic acid, also known as flurbiprofen, is a nonsteroidal anti-inflammatory drug (NSAID) that is used to relieve pain and reduce inflammation in conditions such as rheumatoid arthritis and osteoarthritis. Its chemical structure consists of a 4-fluorophenyl group attached to a methylpropanoic acid moiety, giving it its analgesic and anti-inflammatory properties. Flurbiprofen works by inhibiting the production of prostaglandins, which are compounds responsible for causing pain and inflammation. It is available in various forms, including oral tablets, eye drops, and topical gels, and is commonly prescribed for its effectiveness in managing pain and inflammation. However, like other NSAIDs, flurbiprofen may have potential side effects such as stomach ulcers, kidney problems, and cardiovascular issues. Therefore, it is important to use this medication under the guidance of a healthcare professional.

Upstream product

• 1035261-07-4 ethyl 2-(4-fluorophenyl)-2-methylpropanoate 

Downstream Products

• 82278-19-1 C₁₀H₁₀ClFO 
• 957139-97-8 6-fluoro-N-(2-(4-fluorophenyl)-2-methylpropanoyloxy)-7-morpholino-4-oxo-1-(1-(4-(trifluoromethyl)phenyl)ethyl)-1,4-dihydroquinoline-3-carboximidamide 
• 957138-30-6 6-fluoro-N'-(2-(4-fluorophenyl)-2-methylpropanoyl)-7-morpholino-4-oxo-1-(4-(trifluoromethyl)benzyl)-1,4-dihydroquinoline-3-carbohydrazide 
• 1305196-61-5 C₂₅H₂₈FN₃O₃ 
• 703-10-6 2,2-Dimethyl-2-(4-fluorophenyl)ethanol 
• 1205638-74-9 2-(4-fluorophenyl)-2-methylpropanal 
• 1035261-08-5 diethyl 2-(2-(4-fluorophenyl)-2-methylpropanoyl)malonate 
• 16483-40-2 2,3-Bis(4-fluorphenyl)-2,3-dimethylbutan 

Relevant articles and documents

A α - (4 - substituted phenyl) of isobutyric acid preparation method

The invention relates to the field of organic chemical synthesis and discloses a preparation method of alpha-(4-substituted phenyl)isobutyric acid. The method comprises the steps of respectively carrying out Friedel-Crafts acylation, condensation reaction, rearrangement reaction and hydrolytic acidification reaction on single substituted benzene and 2-haloisobutyryl halide or isobutyryl halide serving as an acylating agent to finally prepare a finished product of alpha-(4-substituted phenyl)isobutyric acid. The preparation method provided by the invention has the advantages that the raw materials are easily obtained and are relatively low in toxicity, a catalysis system of the rearrangement reaction can effectively promote the rearrangement reaction, the obtained product is relatively high in purity and yield, the whole preparation method is simple, the adopted reagent is safe, and the preparation method is beneficial to industrial production.

TRIAZOLOPYRIDINE ETHER DERIVATIVES AND THEIR USE IN NEUROLOGICAL AND PYSCHIATRIC DISORDERS

The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds modulate the mGluR2 receptor and may be useful for the treatment of various disorders of the central nervous system.

NAPHTHALENONE COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, COMPOSITIONS, AND USES THEREOF

Compounds of Formula (I) and Formula (II) are useful as inhibitors of HIF prolyl hydroxylases. Compounds of Formula(I) and Formula (II) have the following structures, where the definitions of the variables are provided herein.