13081-18-0 Usage
Chemical Description
Ethyl trifluoropyruvate is a starting material for the synthesis of the novel diazo compound.
Description
Ethyl trifluoropyruvate, also known as ethyl 3,3,3-trifluoropyruvate, is a trifluoromethylated compound characterized by its clear pale yellow liquid appearance. It is a versatile reagent in the field of synthetic chemistry, particularly for the preparation of biologically active compounds and fluorine-containing compounds.
Uses
Used in Pharmaceutical Industry:
Ethyl trifluoropyruvate is used as a reagent for the preparation of potential biologically active compounds, such as in the highly enantioselective organocatalytic hydroxyalkylation of indoles. This application is significant for the development of new drugs and therapeutic agents.
Used in Synthetic Chemistry:
In the field of synthetic chemistry, ethyl trifluoropyruvate acts as a building block for the synthesis of fluorine-containing compounds. Its unique properties make it a valuable component in the creation of various complex molecules.
Used in the Preparation of N-heteroaryl(trifluoromethyl)hydroxyalkanoic Acid Esters:
Ethyl 3,3,3-trifluoropyruvate may be used in the preparation of N-heteroaryl(trifluoromethyl)hydroxyalkanoic acid esters, which are important intermediates in the synthesis of various pharmaceuticals and bioactive molecules.
General Description:
Ethyl 3,3,3-trifluoropyruvate is a trifluoromethylated compound with clear pale yellow liquid properties. It has been reported to undergo enantioselective Friedel–Crafts alkylation with simple phenols and indoles under different reaction conditions, showcasing its potential in various chemical reactions and applications.
Check Digit Verification of cas no
The CAS Registry Mumber 13081-18-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,0,8 and 1 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 13081-18:
(7*1)+(6*3)+(5*0)+(4*8)+(3*1)+(2*1)+(1*8)=70
70 % 10 = 0
So 13081-18-0 is a valid CAS Registry Number.
InChI:InChI=1/C4H3F3O3/c1-10-3(9)2(8)4(5,6)7/h1H3
13081-18-0Relevant articles and documents
REACTIONS OF BROMORTRIFLUOROMETHANE WITH ACID DERIVATIVES IN THE PRESENCE OF ZINC.
Francese, C.,Tordeux, M.,Wakselman, C.
, p. 1029 - 1030 (1988)
Reaction of zinc with bromotrifluoromethane in pyridine gives poorly reactive trifluoromethyl zinc derivatives in the presence of ethyl benzoate whereas the Barbier condensation occurs with activated esters, like ethyl trifluoroacetate or ethyl oxalate, and cyclic anhydrides.
Synthesis of fluorinated 1,2,3-butatrienes from α-halovinyl organometallic reagents
Morken,Bachand, Patrick C.,Swenson, Dale C.,Burton, Donald J.
, p. 5430 - 5439 (2007/10/02)
The thermal stability and dimerization reaction of fluorinated α-halovinyl zinc and copper reagents, RR'C=CYM (Y = F, Cl, Br; M = ZnX, Cu), have been explored in detail. Dimerization of these vinyl carbenoids to betatrienes occurred when R was an aromatic (C6H5 or C6F5) and R' was a perfluoroalkyl group (CF3, C2F5, C3F7). The role of the α-halogen was determined; the α-F vinyl copper reagent (R = C6H5, R' = CF3) decomposed by oxidative dimerization to 1,3-dienes while the α-Br and -Cl copper reagents dimerized to butatrienes. The fluorinated butatrienes prepared in this study, (E)- and (Z)-R1R2C==C=C=CR1R2 (R1 = CF3, R2 = C6H5; R1 = C2F5, R2 = C6H5; R1 = n-C3F7, R2 = C6H5; R1 = CF3, R2 = C6F5) are available on a multigram scale and readily obtained with high isomeric purity. The geometry of one member of each isomeric pair of butatrienes was characterized by X-ray crystallography. The mechanism of the dimerization reaction has been determined to be a nucleophilic displacement/β-elimination process. Diels-Alder (1,2-addition), bromination (1,2-addition), and isomerizatioa reactions are described.
Process for the preparation of perfluoroalkyl ketones
-
, (2008/06/13)
A process for the preparation of a perfluoroalkyl ketone. A perfluoroalkyl halide, zinc and an ester are brought into contact with one another. Preferably a polar aprotic solvent and/or a pyridine is also present.