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China Synchem Technology Co.,Ltd

Ethyl 3,3,3-trifluoropyruvate Commercial product High purity ≥98.0% Customized product Our Key Technology: 1. Low Temperature Reactions 2. Coupling Reactions 3. Fluorine Chemistry 4. Asymmetric Hydrogenat

Ethyl 3,3,3-trifluoropyruvate

Cas:13081-18-0

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price in China. If you are looking for the product’s supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product specifica

Ethyl trifluoropyruvate

Cas:13081-18-0

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Ethyl Trifluoropyruvate supplier in China

Cas:13081-18-0

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Jinan Finer Chemical Co., Ltd

Product description: Product name Ethyl trifluoropyruvate CAS number 13081-18-0 Assay ≥99% Appearance Yellow to yellowish transparent liquid Capacity 200mt/year Application O

Ethyl trifluoropyruvate

Cas:13081-18-0

Min.Order:1 Kilogram

FOB Price: $12.0

Type:Lab/Research institutions

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Ethyl Trifluoropyruvate

Cas:13081-18-0

Min.Order:1

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Type:Other

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Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

Ethyl trifluoropyruvate

Cas:13081-18-0

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

Ethyl trifluoropyruvate

Cas:13081-18-0

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

Ethyl Trifluoropyruvate

Cas:13081-18-0

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

3,3,3-Trifluoropyruvic acid ethyl ester

Cas:13081-18-0

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

TIANFUCHEM--13081-18-0--Ethyl trifluoropyruvate factory price Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had established stable business

TIANFUCHEM--13081-18-0--Ethyl trifluoropyruvate factory price

Cas:13081-18-0

Min.Order:1 Metric Ton

FOB Price: $2000.0

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Manufacturer supply CAS 13081-18-0 with best quality

Cas:13081-18-0

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developmen

Ethyl trifluoropyruvate CAS NO.13081-18-0

Cas:13081-18-0

Min.Order:1 Kilogram

FOB Price: $2.0 / 6.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Product Name Ethyl trifluoropyruvate Synonyms Ethyl trifluoropyruvate;Trifluoropyruvic acid ethyl ester CAS: 13081-18-0 MF: - MW: -

Ethyl 3,3,3-trifluoropyruvate CAS: 13081-18-0

Cas:13081-18-0

Min.Order:5 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Ethyl trifluoropyruvate 13081-18-0

Cas:13081-18-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Ethyl trifluoropyruvate

Cas:13081-18-0

Min.Order:1 Kilogram

FOB Price: $85.0 / 96.0

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Ethyl trifluoropyruvate/ LIDE PHARMA- Factory supply / Best price

Cas:13081-18-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Changchun Artel lmport and Export trade company

Minimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,MoneyGram Package 10g,20g,50g,100g,500g,1KGS,

Ethyl trifluoropyruvate supplier in China in stock CAS NO.13081-18-0

Cas:13081-18-0

Min.Order:10 Gram

Negotiable

Type:Trading Company

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Ethyl trifluoropyruvate

Cas:13081-18-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

Ethyl Trifluoropyruvate

Cas:13081-18-0

Min.Order:0

Negotiable

Type:Manufacturers

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Ethyl trifluoropyruvate

Cas:13081-18-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Ethyl 3,3,3-trifluoropyruvate

Cas:13081-18-0

Min.Order:100 Gram

Negotiable

Type:Other

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Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

Ethyl trifluoropyruvate/Manufacturer/High quality/Best price

Cas:13081-18-0

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Siwei Development Group Ltd.

Product name: Ethyl Trifluoropyruvate CAS No.: 13081-18-0 Molecule Formula:C4H3F3O3 Molecule Weight:156.06 Purity: 99.0% Package: 250kg/drum Description:Yellow to pale yellow clear liquid Manufacture Standards:Enterprise Standard

Lower Price Ethyl Trifluoropyruvate

Cas:13081-18-0

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Ethyl trifluoropyruvate

Cas:13081-18-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Ethyltrifluoropyruvate

Cas:13081-18-0

Min.Order:1 Milligram

Negotiable

Type:Trading Company

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Shanghai Minstar Chemical Co., Ltd

Product Name: Ethyl trifluoropyruvate CAS: 13081-18-0 MF: C5H5F3O3 MW: 170.09 EINECS: Mol File: 13081-18-0.mol Ethyl trifluoropyruvate Structure Ethyl trifluoropyruvate Chemical Properties Boiling point 42 °C(lit.) densit

Ethyl trifluoropyruvate

Cas:13081-18-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

Ethyl trifluoropyruvate

Cas:13081-18-0

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

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Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

Ethyltrifluoropyruvate

Cas:13081-18-0

Min.Order:0

Negotiable

Type:Manufacturers

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Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

Ethyl trifluoropyruvate

Cas:13081-18-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

Ethyl trifluoropyruvate

Cas:13081-18-0

Min.Order:1 Kilogram

Negotiable

Type:Other

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Synthetic route

2-fluoro-2-ethoxy-trifluoropropionic acid ethyl ester
10186-66-0

2-fluoro-2-ethoxy-trifluoropropionic acid ethyl ester

ethyl-3,3,3-trifluoropyruvate
13081-18-0

ethyl-3,3,3-trifluoropyruvate

Conditions
ConditionsYield
With SbF583%
With sulfuric acid; silica gel
With sulfuric acid; silica gel at 140℃;
2-fluoro-2-ethoxy-trifluoropropionic acid ethyl ester
10186-66-0

2-fluoro-2-ethoxy-trifluoropropionic acid ethyl ester

A

1-fluoroethane
353-36-6

1-fluoroethane

B

ethyl-3,3,3-trifluoropyruvate
13081-18-0

ethyl-3,3,3-trifluoropyruvate

Conditions
ConditionsYield
antimony pentafluoride In neat (no solvent)A n/a
B 83%
ethyl 3,3,3-trifluoro-2-hydroxypropanoate
94726-00-8

ethyl 3,3,3-trifluoro-2-hydroxypropanoate

ethyl-3,3,3-trifluoropyruvate
13081-18-0

ethyl-3,3,3-trifluoropyruvate

Conditions
ConditionsYield
With sodium hypochlorite pentahydrate In acetonitrile at 20℃; for 0.5h; Reagent/catalyst; Solvent;69%
ethyl 3,3,3-trifluoropyruvate ethylhemiketal
26728-43-8

ethyl 3,3,3-trifluoropyruvate ethylhemiketal

ethyl-3,3,3-trifluoropyruvate
13081-18-0

ethyl-3,3,3-trifluoropyruvate

Conditions
ConditionsYield
With sulfuric acid under 16.5017 - 49.505 Torr;67%
Bromotrifluoromethane
75-63-8

Bromotrifluoromethane

oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

ethyl-3,3,3-trifluoropyruvate
13081-18-0

ethyl-3,3,3-trifluoropyruvate

Conditions
ConditionsYield
With zinc In pyridine at 20℃; for 2h; other esters; other perfluoroalkyl iodide;38%
With zinc In pyridine at 20℃; for 2h;38%
With zinc In pyridine at 20℃; 1) pyridine, 20 deg C;38%
ethanol
64-17-5

ethanol

α,α-dihydroxyperfluoropropionic acid
10321-14-9

α,α-dihydroxyperfluoropropionic acid

ethyl-3,3,3-trifluoropyruvate
13081-18-0

ethyl-3,3,3-trifluoropyruvate

Conditions
ConditionsYield
With hydrogenchloride Heating;
Hexafluoropropene oxide
428-59-1

Hexafluoropropene oxide

ethanol
64-17-5

ethanol

ethyl-3,3,3-trifluoropyruvate
13081-18-0

ethyl-3,3,3-trifluoropyruvate

allylbenzene
300-57-2

allylbenzene

ethyl-3,3,3-trifluoropyruvate
13081-18-0

ethyl-3,3,3-trifluoropyruvate

(E)-2-hydroxy-5-phenyl-2-trifluoromethyl-pent-4-enoic acid ethyl ester

(E)-2-hydroxy-5-phenyl-2-trifluoromethyl-pent-4-enoic acid ethyl ester

Conditions
ConditionsYield
silver hexafluoroantimonate; (S)-SEGPHOS-PdCl2 In dichloromethane at 20℃; for 0.5h; Ene reaction;100%
With silver hexafluoroantimonate; (R)-(2,2'-bis(diphenylphosphanyl)biphenyl)dichloroplatinum(II) In dichloromethane at -20℃; for 1h;83%
ethyl-3,3,3-trifluoropyruvate
13081-18-0

ethyl-3,3,3-trifluoropyruvate

methylenecyclohexane
1192-37-6

methylenecyclohexane

ethyl 2-(cyclohexenylmethyl)-3,3,3-trifluoro-2-hydroxypropanoate

ethyl 2-(cyclohexenylmethyl)-3,3,3-trifluoro-2-hydroxypropanoate

Conditions
ConditionsYield
silver hexafluoroantimonate; (S)-SEGPHOS-PdCl2 In dichloromethane at 20℃; for 0.25h; Ene reaction;100%
With silver hexafluoroantimonate; [(R)-BINAPHANE]PdCl2 In dichloromethane at 20℃; for 1h; Inert atmosphere; optical yield given as %ee; enantioselective reaction;78%
With silver hexafluoroantimonate; chiral SEGPHOS-Pd(II) In dichloromethane at 20℃; for 0.25h; Friedel-Crafts reaction;
allylbenzene
300-57-2

allylbenzene

ethyl-3,3,3-trifluoropyruvate
13081-18-0

ethyl-3,3,3-trifluoropyruvate

2-hydroxy-5-phenyl-2-trifluoromethyl-pent-4-enoic acid ethyl ester

2-hydroxy-5-phenyl-2-trifluoromethyl-pent-4-enoic acid ethyl ester

Conditions
ConditionsYield
With silver hexafluoroantimonate; chiral SEGPHOS-Pd(II) In dichloromethane at 20℃; for 0.5h; Friedel-Crafts reaction;100%
methanol
67-56-1

methanol

ethyl-3,3,3-trifluoropyruvate
13081-18-0

ethyl-3,3,3-trifluoropyruvate

ethyl 3,3,3-trifluoropyruvate methylhemiketal

ethyl 3,3,3-trifluoropyruvate methylhemiketal

Conditions
ConditionsYield
at 20℃;100%
ethyl-3,3,3-trifluoropyruvate
13081-18-0

ethyl-3,3,3-trifluoropyruvate

1,2-diamino-benzene
95-54-5

1,2-diamino-benzene

3-(trifluoromethyl)quinoxalin-2-ol
58457-64-0

3-(trifluoromethyl)quinoxalin-2-ol

Conditions
ConditionsYield
In tetrahydrofuran at 45℃;100%
In tetrahydrofuran at 40 - 50℃;
indole
120-72-9

indole

ethyl-3,3,3-trifluoropyruvate
13081-18-0

ethyl-3,3,3-trifluoropyruvate

(2S)-3,3,3-trifluoro-2-hydroxy-2-(indol-3-yl)propionic acid ethyl ester

(2S)-3,3,3-trifluoro-2-hydroxy-2-(indol-3-yl)propionic acid ethyl ester

Conditions
ConditionsYield
Stage #1: ethyl-3,3,3-trifluoropyruvate With copper(II) bis[bis((trifluoromethyl)sulfonyl)amide]; 1,5-bis[(4S,5S)-1-(4-nitrobenzoyl)-4,5-diphenyl-4,5-dihydro-1H-imidazol-2-yl]benzene In toluene at -78℃; Friedel Crafts alkylation; Molecular sieve; Inert atmosphere;
Stage #2: indole In toluene at -78℃; for 4h; Friedel Crafts alkylation; Inert atmosphere; optical yield given as %ee; enantioselective reaction;
99%
With (3aR,11aR,14aS,16bS)-2,2,13,13-tetra-isopropyl-3a,11a,14a,16b-tetrahydro-bis(1,3-dioxolano[4',5':3,4]pyrrolo)[1,2-a:1',2'-a]naphtho[1,2-d:8,7-d']diimidazole; copper(II) bis(trifluoromethanesulfonate) at 0℃; for 1h; Catalytic behavior; Temperature; Friedel-Crafts Alkylation; Inert atmosphere; Schlenk technique; stereoselective reaction;99.3%
Stage #1: indole With C78H78N12O6 In tetrahydrofuran at -20℃; for 0.5h; Inert atmosphere;
Stage #2: ethyl-3,3,3-trifluoropyruvate In tetrahydrofuran at -20℃; for 12h; Inert atmosphere; enantioselective reaction;
92%
With (3aS,11aS,14aR,16bR)-2,2,13,13-tetra-isopropyl-3a,11a,14a,16b-tetrahydro-bis(1,3-dioxolano[4',5':3,4]pyrrolo)[1,2-a:1',2'-a]naphtho[1,2-d:8,7-d']diimidazole; (3aR,11aR,14aS,16bS)-2,2,13,13-tetra-isopropyl-3a,11a,14a,16b-tetrahydro-bis(1,3-dioxolano[4',5':3,4]pyrrolo)[1,2-a:1',2'-a]naphtho[1,2-d:8,7-d']diimidazole; copper(II) bis(trifluoromethanesulfonate) at 0℃; for 1h; Friedel-Crafts Alkylation; Schlenk technique; Inert atmosphere; enantioselective reaction;
ethyl-3,3,3-trifluoropyruvate
13081-18-0

ethyl-3,3,3-trifluoropyruvate

5-chloro-1H-indole
17422-32-1

5-chloro-1H-indole

(S)-3,3,3-trifluoro-2-hydroxy-2-(5-chloroindol-3-yl)propionic acid ethyl ester

(S)-3,3,3-trifluoro-2-hydroxy-2-(5-chloroindol-3-yl)propionic acid ethyl ester

Conditions
ConditionsYield
Stage #1: ethyl-3,3,3-trifluoropyruvate With copper(II) bis[bis((trifluoromethyl)sulfonyl)amide]; 1,5-bis[(4S,5S)-1-(4-nitrobenzoyl)-4,5-diphenyl-4,5-dihydro-1H-imidazol-2-yl]benzene In toluene at -78℃; Friedel Crafts alkylation; Molecular sieve; Inert atmosphere;
Stage #2: 5-chloro-1H-indole In toluene at -78℃; for 17h; Friedel Crafts alkylation; Inert atmosphere; optical yield given as %ee; enantioselective reaction;
99%
Stage #1: 5-chloro-1H-indole With C33H52N4O4; zinc trifluoromethanesulfonate In dichloromethane at 35℃; for 0.5h;
Stage #2: ethyl-3,3,3-trifluoropyruvate In dichloromethane at 0℃; for 0.5h; Friedel Crafts alkylation; optical yield given as %ee; enantioselective reaction;
99%
With (3aR,11aR,14aS,16bS)-2,2,13,13-tetra-isopropyl-3a,11a,14a,16b-tetrahydro-bis(1,3-dioxolano[4',5':3,4]pyrrolo)[1,2-a:1',2'-a]naphtho[1,2-d:8,7-d']diimidazole; copper(II) bis(trifluoromethanesulfonate) at 0℃; for 1h; Friedel-Crafts Alkylation; Inert atmosphere; Schlenk technique; stereoselective reaction;99.3%
With cinchonidine In diethyl ether at -8℃;
5-bromo-1H-indole
10075-50-0

5-bromo-1H-indole

ethyl-3,3,3-trifluoropyruvate
13081-18-0

ethyl-3,3,3-trifluoropyruvate

(S)-3,3,3-trifluoro-2-hydroxy-2-(5-bromoindol-3-yl)propionic acid ethyl ester

(S)-3,3,3-trifluoro-2-hydroxy-2-(5-bromoindol-3-yl)propionic acid ethyl ester

Conditions
ConditionsYield
Stage #1: 5-bromo-1H-indole With C33H52N4O4; zinc trifluoromethanesulfonate In dichloromethane at 35℃; for 0.5h;
Stage #2: ethyl-3,3,3-trifluoropyruvate In dichloromethane at 0℃; for 0.5h; Friedel Crafts alkylation; optical yield given as %ee; enantioselective reaction;
99%
With (3aR,11aR,14aS,16bS)-2,2,13,13-tetra-isopropyl-3a,11a,14a,16b-tetrahydro-bis(1,3-dioxolano[4',5':3,4]pyrrolo)[1,2-a:1',2'-a]naphtho[1,2-d:8,7-d']diimidazole; copper(II) bis(trifluoromethanesulfonate) at 0℃; for 1h; Friedel-Crafts Alkylation; Inert atmosphere; Schlenk technique; stereoselective reaction;99.1%
Stage #1: ethyl-3,3,3-trifluoropyruvate With copper(II) bis[bis((trifluoromethyl)sulfonyl)amide]; 1,5-bis[(4S,5S)-1-(4-nitrobenzoyl)-4,5-diphenyl-4,5-dihydro-1H-imidazol-2-yl]benzene In toluene at -78℃; Friedel Crafts alkylation; Molecular sieve; Inert atmosphere;
Stage #2: 5-bromo-1H-indole In toluene at -78℃; for 17h; Friedel Crafts alkylation; Inert atmosphere; optical yield given as %ee; enantioselective reaction;
96%
With cinchonidine In diethyl ether at -8℃;
With cinchonidine In diethyl ether at -8℃; for 3h; enantioselective reaction;
carbamic acid-(1-trichloromethyl-1-methyl-ethyl ester)
89416-45-5

carbamic acid-(1-trichloromethyl-1-methyl-ethyl ester)

ethyl-3,3,3-trifluoropyruvate
13081-18-0

ethyl-3,3,3-trifluoropyruvate

Ethyl 2-(2,2,2-Trichloro-tert-butoxycarbonylamino)-2-hydroxy-3,3,3-trifluoropropionate
126535-85-1

Ethyl 2-(2,2,2-Trichloro-tert-butoxycarbonylamino)-2-hydroxy-3,3,3-trifluoropropionate

Conditions
ConditionsYield
In dichloromethane99%
ethyl-3,3,3-trifluoropyruvate
13081-18-0

ethyl-3,3,3-trifluoropyruvate

benzamide
55-21-0

benzamide

Ethyl 2-benzoylamino-2-hydroxy-3,3,3-trifluoropropionate
126535-81-7

Ethyl 2-benzoylamino-2-hydroxy-3,3,3-trifluoropropionate

Conditions
ConditionsYield
In dichloromethane for 2h; Ambient temperature;99%
indole
120-72-9

indole

ethyl-3,3,3-trifluoropyruvate
13081-18-0

ethyl-3,3,3-trifluoropyruvate

(+/-)-3,3,3-trifluoro-2-hydroxy-2-(indol-3-yl)propionic acid ethyl ester

(+/-)-3,3,3-trifluoro-2-hydroxy-2-(indol-3-yl)propionic acid ethyl ester

Conditions
ConditionsYield
With (SIr,RC)-[(η5-C5Me5)Ir{(R)-propane-1,2-diylbis(diphenylphosphane)}(H2O)][SbF6]2 In dichloromethane for 0.333333h; Friedel-Crafts Alkylation; Inert atmosphere; Schlenk technique; Optical yield = 65 %ee;99%
With gallium(III) triflate In dichloromethane at 20℃; for 2h; Friedel-Crafts hydroxyalkylation;98%
With K-10 montmorillonite In toluene at 60℃; for 0.0666667h; Friedel-Crafts hydroxyalkylation;98%
1-methylindole
603-76-9

1-methylindole

ethyl-3,3,3-trifluoropyruvate
13081-18-0

ethyl-3,3,3-trifluoropyruvate

3,3,3-trifluoro-2-hydroxy-2-(1-methyl-indol-3-yl)-propionic acid ethyl ester

3,3,3-trifluoro-2-hydroxy-2-(1-methyl-indol-3-yl)-propionic acid ethyl ester

Conditions
ConditionsYield
With gallium(III) triflate In dichloromethane at 20℃; for 2h; Friedel-Crafts hydroxyalkylation;99%
With (SIr,RC)-[(η5-C5Me5)Ir{(R)-propane-1,2-diylbis(diphenylphosphane)}(H2O)][SbF6]2 In dichloromethane for 0.333333h; Friedel-Crafts Alkylation; Inert atmosphere; Schlenk technique; Optical yield = 47 %ee;99%
With K-10 montmorillonite In toluene at 60℃; for 0.0666667h; Friedel-Crafts hydroxyalkylation;95%
2-methyl-1H-indole
95-20-5

2-methyl-1H-indole

ethyl-3,3,3-trifluoropyruvate
13081-18-0

ethyl-3,3,3-trifluoropyruvate

3,3,3-trifluoro-2-hydroxy-2-(2-methyl-1H-indol-3-yl)-propionic acid ethyl ester

3,3,3-trifluoro-2-hydroxy-2-(2-methyl-1H-indol-3-yl)-propionic acid ethyl ester

Conditions
ConditionsYield
With (SIr,RC)-[(η5-C5Me5)Ir{(R)-propane-1,2-diylbis(diphenylphosphane)}(H2O)][SbF6]2 In dichloromethane for 0.416667h; Friedel-Crafts Alkylation; Inert atmosphere; Schlenk technique; Optical yield = 76 %ee;99%
With K-10 montmorillonite In toluene at 60℃; for 0.0833333h; Friedel-Crafts hydroxyalkylation;97%
With aluminum (III) chloride In dichloromethane at 20℃; Friedel-Crafts Acylation;93%
In 1,1,1,3,3-pentafluorobutane at 20℃; for 0.5h; Inert atmosphere;91%
With N2,N2'-bis(pyridin-2-ylmethyl)-1,1'-binaphthyl-2,2'-diamine In dichloromethane at 0℃; for 24h; Friedel-Crafts Alkylation; enantioselective reaction;87%
5-methoxylindole
1006-94-6

5-methoxylindole

ethyl-3,3,3-trifluoropyruvate
13081-18-0

ethyl-3,3,3-trifluoropyruvate

3,3,3-trifluoro-2-hydroxy-2-(5-methoxy-1H-indol-3-yl)-propionic acid ethyl ester

3,3,3-trifluoro-2-hydroxy-2-(5-methoxy-1H-indol-3-yl)-propionic acid ethyl ester

Conditions
ConditionsYield
With (SIr,RC)-[(η5-C5Me5)Ir{(R)-propane-1,2-diylbis(diphenylphosphane)}(H2O)][SbF6]2 In dichloromethane for 0.333333h; Friedel-Crafts Alkylation; Inert atmosphere; Schlenk technique; Optical yield = 71 %ee;99%
With K-10 montmorillonite In toluene at 60℃; for 0.0833333h; Friedel-Crafts hydroxyalkylation;97%
In 1,1,1,3,3-pentafluorobutane at 20℃; for 0.5h; Inert atmosphere;96%
ethyl-3,3,3-trifluoropyruvate
13081-18-0

ethyl-3,3,3-trifluoropyruvate

3-phenylaminocyclohex-2-enone
24706-50-1

3-phenylaminocyclohex-2-enone

3-hydroxy-1-phenyl-3-trifluoromethyl-3,5,6,7-tetrahydro-1H-indole-2,4-dione

3-hydroxy-1-phenyl-3-trifluoromethyl-3,5,6,7-tetrahydro-1H-indole-2,4-dione

Conditions
ConditionsYield
In dichloromethane at 20℃; for 0.5h; aldol condensation-cyclization;99%
ethyl-3,3,3-trifluoropyruvate
13081-18-0

ethyl-3,3,3-trifluoropyruvate

5,5-dimethyl-3-benzylamino-2-cyclohexen-1-one
889-31-6

5,5-dimethyl-3-benzylamino-2-cyclohexen-1-one

1-benzyl-3-hydroxy-6,6-dimethyl-3-trifluoromethyl-4,5,6,7-tetrahydro-1H-indole-2,4-dione

1-benzyl-3-hydroxy-6,6-dimethyl-3-trifluoromethyl-4,5,6,7-tetrahydro-1H-indole-2,4-dione

Conditions
ConditionsYield
In dichloromethane at 20℃; for 0.5h; aldol condensation-cyclization;99%
ethyl-3,3,3-trifluoropyruvate
13081-18-0

ethyl-3,3,3-trifluoropyruvate

3-(benzylamino)cyclopent-2-en-1-one
149221-40-9

3-(benzylamino)cyclopent-2-en-1-one

2-(2-benzylamino-5-oxo-cyclopent-1-enyl)-3,3,3-trifluoro-2-hydroxy-propionic acid ethyl ester

2-(2-benzylamino-5-oxo-cyclopent-1-enyl)-3,3,3-trifluoro-2-hydroxy-propionic acid ethyl ester

Conditions
ConditionsYield
In dichloromethane at 20℃; for 0.5h; aldol condensation;99%
indole
120-72-9

indole

ethyl-3,3,3-trifluoropyruvate
13081-18-0

ethyl-3,3,3-trifluoropyruvate

(2R)-3,3,3-trifluoro-2-hydroxy-2-(indol-3-yl)propionic acid ethyl ester

(2R)-3,3,3-trifluoro-2-hydroxy-2-(indol-3-yl)propionic acid ethyl ester

Conditions
ConditionsYield
With C32H40N4O4; copper(II) bis(trifluoromethanesulfonate) at 0℃; for 1h; Friedel-Crafts Alkylation; Inert atmosphere; Schlenk technique; stereoselective reaction;99%
Stage #1: indole With C33H52N4O4; zinc trifluoromethanesulfonate In dichloromethane at 35℃; for 0.5h;
Stage #2: ethyl-3,3,3-trifluoropyruvate In dichloromethane at 0℃; for 0.5h; Friedel Crafts alkylation; optical yield given as %ee; enantioselective reaction;
98%
Stage #1: ethyl-3,3,3-trifluoropyruvate With copper (I) trifluoromethane sulfonate toluene complex; C24H26N2O2 In diethyl ether at -98 - 20℃; for 0.333333h; Inert atmosphere;
Stage #2: indole In diethyl ether at -98℃; for 1.5h; Friedel Crafts acylation; Inert atmosphere; optical yield given as %ee; enantioselective reaction;
98%
Stage #1: ethyl-3,3,3-trifluoropyruvate With 2,6-bis(1-[toluene-4-sulfonyl]-[4S,5S]-4,5-diphenyl-4,5-dihydro-1H-imidazol-2-yl)benzene; copper(II) bis(trifluoromethanesulfonate) In dichloromethane at -78℃; for 0.5h; Friedel Crafts alkylation; Molecular sieve; Inert atmosphere;
Stage #2: indole In dichloromethane at -78℃; for 3h; Friedel Crafts alkylation; Inert atmosphere; optical yield given as %ee; enantioselective reaction;
95%
With Cu(2+)*2C32H40N4O4; Cu(2+)*C32H40N4O4 at 0℃; for 1h; Friedel-Crafts Alkylation; Schlenk technique; Inert atmosphere; enantioselective reaction;
5-fluoro-1H-indole
399-52-0

5-fluoro-1H-indole

ethyl-3,3,3-trifluoropyruvate
13081-18-0

ethyl-3,3,3-trifluoropyruvate

3,3,3-trifluoro-2-hydroxy-2-(5-fluoro-1H-indol-3-yl)-propionic acid ethyl ester

3,3,3-trifluoro-2-hydroxy-2-(5-fluoro-1H-indol-3-yl)-propionic acid ethyl ester

Conditions
ConditionsYield
Stage #1: ethyl-3,3,3-trifluoropyruvate With copper(II) bis[bis((trifluoromethyl)sulfonyl)amide]; 1,5-bis[(4S,5S)-1-(4-nitrobenzoyl)-4,5-diphenyl-4,5-dihydro-1H-imidazol-2-yl]benzene In toluene at -78℃; Friedel Crafts alkylation; Molecular sieve; Inert atmosphere;
Stage #2: 5-fluoro-1H-indole In toluene at -78℃; for 4h; Friedel Crafts alkylation; Inert atmosphere; optical yield given as %ee; enantioselective reaction;
99%
Stage #1: 5-fluoro-1H-indole With C33H52N4O4; zinc trifluoromethanesulfonate In dichloromethane at 35℃; for 0.5h;
Stage #2: ethyl-3,3,3-trifluoropyruvate In dichloromethane at 0℃; for 0.5h; Friedel Crafts alkylation; optical yield given as %ee; enantioselective reaction;
99%
With (3aR,11aR,14aS,16bS)-2,2,13,13-tetra-isopropyl-3a,11a,14a,16b-tetrahydro-bis(1,3-dioxolano[4',5':3,4]pyrrolo)[1,2-a:1',2'-a]naphtho[1,2-d:8,7-d']diimidazole; copper(II) bis(trifluoromethanesulfonate) at 0℃; for 1h; Friedel-Crafts Alkylation; Inert atmosphere; Schlenk technique; stereoselective reaction;98.6%
Stage #1: 5-fluoro-1H-indole With C78H78N12O6 In tetrahydrofuran at -20℃; for 0.5h; Inert atmosphere;
Stage #2: ethyl-3,3,3-trifluoropyruvate In tetrahydrofuran at -20℃; for 12h; Inert atmosphere; enantioselective reaction;
87%
5-iodo-1H-indole
16066-91-4

5-iodo-1H-indole

ethyl-3,3,3-trifluoropyruvate
13081-18-0

ethyl-3,3,3-trifluoropyruvate

(S)-3,3,3-trifluoro-2-hydroxy-2-(5-iodoindol-3-yl)propionic acid ethyl ester

(S)-3,3,3-trifluoro-2-hydroxy-2-(5-iodoindol-3-yl)propionic acid ethyl ester

Conditions
ConditionsYield
Stage #1: ethyl-3,3,3-trifluoropyruvate With copper(II) bis[bis((trifluoromethyl)sulfonyl)amide]; 1,5-bis[(4S,5S)-1-(4-nitrobenzoyl)-4,5-diphenyl-4,5-dihydro-1H-imidazol-2-yl]benzene In toluene at -78℃; Friedel Crafts alkylation; Molecular sieve; Inert atmosphere;
Stage #2: 5-iodo-1H-indole In toluene at -78℃; for 17h; Friedel Crafts alkylation; Inert atmosphere; optical yield given as %ee; enantioselective reaction;
99%
With (3aR,11aR,14aS,16bS)-2,2,13,13-tetra-isopropyl-3a,11a,14a,16b-tetrahydro-bis(1,3-dioxolano[4',5':3,4]pyrrolo)[1,2-a:1',2'-a]naphtho[1,2-d:8,7-d']diimidazole; copper(II) bis(trifluoromethanesulfonate) at 0℃; for 1h; Friedel-Crafts Alkylation; Inert atmosphere; Schlenk technique; stereoselective reaction;98.6%
With cinchonidine In diethyl ether at -8℃;
ethyl-3,3,3-trifluoropyruvate
13081-18-0

ethyl-3,3,3-trifluoropyruvate

5-chloro-1H-indole
17422-32-1

5-chloro-1H-indole

(R)-3,3,3-trifluoro-2-hydroxy-2-(5-chloroindol-3-yl)propionic acid ethyl ester

(R)-3,3,3-trifluoro-2-hydroxy-2-(5-chloroindol-3-yl)propionic acid ethyl ester

Conditions
ConditionsYield
Stage #1: 5-chloro-1H-indole With C33H52N4O4; zinc trifluoromethanesulfonate In dichloromethane at 35℃; for 0.5h;
Stage #2: ethyl-3,3,3-trifluoropyruvate In dichloromethane at 0℃; for 0.5h; Friedel Crafts alkylation; optical yield given as %ee; enantioselective reaction;
99%
Stage #1: ethyl-3,3,3-trifluoropyruvate With 2,6-bis(1-[toluene-4-sulfonyl]-[4S,5S]-4,5-diphenyl-4,5-dihydro-1H-imidazol-2-yl)benzene; copper(II) bis(trifluoromethanesulfonate) In dichloromethane at -78℃; for 0.5h; Friedel Crafts alkylation; Molecular sieve; Inert atmosphere;
Stage #2: 5-chloro-1H-indole In dichloromethane at -78℃; for 19h; Friedel Crafts alkylation; Inert atmosphere; optical yield given as %ee; enantioselective reaction;
95%
With cinchonine In diethyl ether at -8℃;
6-methylindole
3420-02-8

6-methylindole

ethyl-3,3,3-trifluoropyruvate
13081-18-0

ethyl-3,3,3-trifluoropyruvate

3,3,3-trifluoro-2-hydroxy-2-(6-methyl-1H-indol-3-yl)-propionic acid ethyl ester
1265815-30-2

3,3,3-trifluoro-2-hydroxy-2-(6-methyl-1H-indol-3-yl)-propionic acid ethyl ester

Conditions
ConditionsYield
In 1,1,1,3,3-pentafluorobutane at 20℃; for 0.5h; Inert atmosphere;99%
With triethylamine In dichloromethane at 0℃; Friedel Crafts alkylation;
With copper(II) bis(trifluoromethanesulfonate) In chloroform at 25℃; for 16h; Friedel-Crafts Alkylation; Inert atmosphere; Schlenk technique;
7-methyl-1H-indole
933-67-5

7-methyl-1H-indole

ethyl-3,3,3-trifluoropyruvate
13081-18-0

ethyl-3,3,3-trifluoropyruvate

3,3,3-trifluoro-2-hydroxy-2-(7-methyl-1H-indol-3-yl)-propionic acid ethyl ester
1262999-81-4

3,3,3-trifluoro-2-hydroxy-2-(7-methyl-1H-indol-3-yl)-propionic acid ethyl ester

Conditions
ConditionsYield
Stage #1: 7-methyl-1H-indole With C33H52N4O4; zinc trifluoromethanesulfonate In dichloromethane at 35℃; for 0.5h;
Stage #2: ethyl-3,3,3-trifluoropyruvate In dichloromethane at 0℃; for 0.5h; Friedel Crafts alkylation; optical yield given as %ee; enantioselective reaction;
99%
With (3aR,11aR,14aS,16bS)-2,2,13,13-tetra-isopropyl-3a,11a,14a,16b-tetrahydro-bis(1,3-dioxolano[4',5':3,4]pyrrolo)[1,2-a:1',2'-a]naphtho[1,2-d:8,7-d']diimidazole; copper(II) bis(trifluoromethanesulfonate) at 0℃; for 1h; Friedel-Crafts Alkylation; Inert atmosphere; Schlenk technique; stereoselective reaction;97.6%
7-methyl-1H-indole
933-67-5

7-methyl-1H-indole

ethyl-3,3,3-trifluoropyruvate
13081-18-0

ethyl-3,3,3-trifluoropyruvate

3,3,3-trifluoro-2-hydroxy-2-(7-methyl-1H-indol-3-yl)-propionic acid ethyl ester
1179934-54-3

3,3,3-trifluoro-2-hydroxy-2-(7-methyl-1H-indol-3-yl)-propionic acid ethyl ester

Conditions
ConditionsYield
In 1,1,1,3,3-pentafluorobutane at 20℃; for 0.5h; Inert atmosphere;99%
With triethylamine In dichloromethane at 0℃; Friedel Crafts alkylation;
With copper(II) bis(trifluoromethanesulfonate) In chloroform at 25℃; for 16h; Friedel-Crafts Alkylation; Inert atmosphere; Schlenk technique;
5-fluoro-1H-indole
399-52-0

5-fluoro-1H-indole

ethyl-3,3,3-trifluoropyruvate
13081-18-0

ethyl-3,3,3-trifluoropyruvate

3,3,3-trifluoro-2-hydroxy-2-(5-fluoro-1H-indol-3-yl)-propionic acid ethyl ester

3,3,3-trifluoro-2-hydroxy-2-(5-fluoro-1H-indol-3-yl)-propionic acid ethyl ester

Conditions
ConditionsYield
Stage #1: 5-fluoro-1H-indole With C33H52N4O4; zinc trifluoromethanesulfonate In dichloromethane at 35℃; for 0.5h;
Stage #2: ethyl-3,3,3-trifluoropyruvate In dichloromethane at 0℃; for 0.5h; Friedel Crafts alkylation; optical yield given as %ee; enantioselective reaction;
99%
7-ethyl-1H-indole
22867-74-9

7-ethyl-1H-indole

ethyl-3,3,3-trifluoropyruvate
13081-18-0

ethyl-3,3,3-trifluoropyruvate

3,3,3-trifluoro-2-hydroxy-2-(7-ethyl-1H-indol-3-yl)-propionic acid ethyl ester
1262999-77-8

3,3,3-trifluoro-2-hydroxy-2-(7-ethyl-1H-indol-3-yl)-propionic acid ethyl ester

Conditions
ConditionsYield
Stage #1: 7-ethyl-1H-indole With C33H52N4O4; zinc trifluoromethanesulfonate In dichloromethane at 35℃; for 0.5h;
Stage #2: ethyl-3,3,3-trifluoropyruvate In dichloromethane at 0℃; for 0.5h; Friedel Crafts alkylation; optical yield given as %ee; enantioselective reaction;
99%
1-ethynyl-2-methylbenzene
766-47-2

1-ethynyl-2-methylbenzene

ethyl-3,3,3-trifluoropyruvate
13081-18-0

ethyl-3,3,3-trifluoropyruvate

ethyl 2-hydroxy-4-p-tolyl-2-(trifluoromethyl)but-3-ynoate

ethyl 2-hydroxy-4-p-tolyl-2-(trifluoromethyl)but-3-ynoate

Conditions
ConditionsYield
With [Rh{(S,S)-4-NO2-Phebox-Bn}(OAc)2]*H2O In diethyl ether at 25℃; for 24h; Inert atmosphere; enantioselective reaction;99%
1-ethynyl-3-methyl-benzene
766-82-5

1-ethynyl-3-methyl-benzene

ethyl-3,3,3-trifluoropyruvate
13081-18-0

ethyl-3,3,3-trifluoropyruvate

ethyl 2-hydroxy-4-m-tolyl-2-(trifluoromethyl)but-3-ynoate

ethyl 2-hydroxy-4-m-tolyl-2-(trifluoromethyl)but-3-ynoate

Conditions
ConditionsYield
With [Rh{(S,S)-4-NO2-Phebox-Bn}(OAc)2]*H2O In diethyl ether at 25℃; for 24h; Inert atmosphere; enantioselective reaction;99%
ethyl-3,3,3-trifluoropyruvate
13081-18-0

ethyl-3,3,3-trifluoropyruvate

phenylacetylene
536-74-3

phenylacetylene

(S)-ethyl 2-hydroxy-4-phenyl-2-(trifluoromethyl)but-3-ynoate
1315273-00-7

(S)-ethyl 2-hydroxy-4-phenyl-2-(trifluoromethyl)but-3-ynoate

Conditions
ConditionsYield
With C54H48N5O7Rh In diethyl ether at 25℃; for 24h; Reagent/catalyst; Solvent; Temperature; Inert atmosphere; Large scale; enantioselective reaction;99%
With [Rh{(S,S)-4-NO2-Phebox-Bn}(OAc)2]*H2O In diethyl ether at 25℃; for 24h; Inert atmosphere; enantioselective reaction;95%
1-[2-(4-methoxyphenyl)ethynyl]-4-nitrobenzene
39082-40-1

1-[2-(4-methoxyphenyl)ethynyl]-4-nitrobenzene

ethyl-3,3,3-trifluoropyruvate
13081-18-0

ethyl-3,3,3-trifluoropyruvate

ethyl 4-(4-methoxyphenyl)-3-(4-nitrophenyl)-2-(trifluoromethyl)-2H-oxete-2-carboxylate

ethyl 4-(4-methoxyphenyl)-3-(4-nitrophenyl)-2-(trifluoromethyl)-2H-oxete-2-carboxylate

Conditions
ConditionsYield
With silver hexafluoroantimonate; (S)-BINAP-PdCl2 In dichloromethane at 0℃; for 12h; Inert atmosphere; optical yield given as %ee; enantioselective reaction;99%
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