130861-73-3

Basic information

• Product Name: 2-Chloro-5,6,7,8-tetrahydro-8-quinolinol
• Synonyms: 2-Chloro-5,6,7,8-tetrahydro-8-quinolinol;2-Chloro-8-hydroxy-5,6,7,8-tetrahydroquinoline;2-Chloro-5,6,7,8-tetrahydroquinolin-8-ol
• CAS NO: 130861-73-3
• Molecular Formula: C₉H₁₀ClNO
• Molecular Weight: 183.6348
• Mol File: 130861-73-3.mol
• Article Data: 11

Chemical Properties

• Melting Point: 53-54℃
• Boiling Point: 331.6°C at 760 mmHg
• Flash Point: 154.4°C
• Appearance: /
• Density: 1.326
• Vapor Pressure: 6.14E-05mmHg at 25°C
• Refractive Index: 1.604
• CAS DataBase Reference: 2-Chloro-5,6,7,8-tetrahydro-8-quinolinol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-5,6,7,8-tetrahydro-8-quinolinol(130861-73-3)
• EPA Substance Registry System: 2-Chloro-5,6,7,8-tetrahydro-8-quinolinol(130861-73-3)

Safety Data

• Hazardous Substances Data: 130861-73-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H10ClNO/c10-8-5-4-6-2-1-3-7(12)9(6)11-8/h4-5,7,12H,1-3H2

Upstream product

• 130861-72-2 2-chloro-5,6,7,8-tetrahydroquinolin-8-yl acetate 
• 130861-71-1 2-chloro-5,6,7,8-tetrahydroquinoline N-oxide 
• 21172-88-3 2-chloro-5,6,7,8-tetrahydro-quinoline 
• 54802-19-6 2-hydroxy-5,6,7,8-tetrahydroquinoline 
• 1351935-49-3 2-chloro-8-(4-methoxybenzyloxy)-5,6,7,8-tetrahydroquinoline 
• 1426306-42-4 C₂₂H₂₀ClNO 
• 129337-86-6 2-chloro-5,6,7,8-tetrahydroquinolin-8-one 
• 108-94-1 cyclohexanone 
• 4471-09-4 N-benzylcyclohexylimine 
• 85031-42-1 N-benzyl-N-(cyclohex-1-enyl)acetamide 
• 100-46-9 benzylamine 

Downstream Products

• 92850-41-4 8-hydroxy-2-phenyl-5,6,7,8-tetrahydroquinoline 
• 14631-46-0 5,6,7,8-tetrahydroquinoline-8-ol 
• 1384895-16-2 2-(1-(2,6-dimethylphenylimino)ethyl)-8-(2,6-dimethylphenylimino)-5,6,7-trihydroquinoline 
• 1351935-49-3 2-chloro-8-(4-methoxybenzyloxy)-5,6,7,8-tetrahydroquinoline 
• 1384895-14-0 1-[8-(4-methoxybenzyloxy)-5,6,7,8-tetrahydroquinolin-2-yl]ethanone 
• 129337-86-6 2-chloro-5,6,7,8-tetrahydroquinolin-8-one 

Relevant articles and documents

HPK1 ANTAGONISTS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of HPK1, and the treatment of HPK1-mediated disorders.

Thermo-enhanced ring-opening polymerization of ?-caprolactone: The synthesis, characterization, and catalytic behavior of aluminum hydroquinolin-8-olates

A series of highly sensitive aluminum hydroquinolin-8-olates (C1-C8) was synthesized and characterized by 1H/13C NMR spectroscopy. The molecular structures of compounds C1, C3, C4, and C5 were confirmed by single crystal X-ray crystallography and demonstrated the binuclear form. In the presence of BnOH, all the aluminum complexes exhibited moderate to high activities towards the ring-opening polymerization of ?-CL at high temperatures, but quite low activities at ambient temperature. Microstructure analysis of the resultant polycaprolactones showed that the polymers were linear in nature with a BnO- end group. In addition, the mechanism was investigated by monitoring the 1H NMR and 27Al NMR of C1 and these results suggested that the complexes existed as dimeric species at low temperature and partly converted into active mononuclear species at higher temperatures, which was easily coordinated by BnOH to afford the active species for the ring-opening polymerization of ?-caprolactone.

A removing the hydroxy group of a benzyl protecting group method (by machine translation)

The invention discloses a process for the removal of the hydroxyl group of a method of a benzyl protecting group, the method is as follows: to the hydroxy compound by the hydroxy group with protection of the benzyl protecting group of the benzyl compound as reaction substrate, in order to 2, the 3 [...] two chloro -5,6 the [...] two cyanato -1, the 4 [...] benzoquinone (DDQ) and phthalocyanine ferrous (Fe II Pc) as catalyst, in order to 4,4 '-bipyridine (4, the 4 [...] -bpy) as an auxiliary agent, with oxygen as the oxidizing agent, in an organic solvent in the reaction substrate, the oxygen pressure 0.3-0.6 MPa, temperature 60-120 °C reaction is carried out under the condition of, removing the hydroxy group of a benzyl protecting group obtain hydroxyl compound. With the traditional use of chemical metering of oxidation with DDQ for the protection, the consumption of DDQ in this invention is greatly reduced, reducing the cost of reaction; with DDQ as catalyst, metal oxide or metal salt is compared with oxidation of the oxidizing agent for the protection, the used in the present invention oxygen as the oxidizing agent, reduces the environmental costs. (by machine translation)