21172-88-3 Usage
General Description
2-chloro-5,6,7,8-tetrahydroquinoline is a chemical compound with the formula C9H10ClN. It is a heterocyclic compound that contains a quinoline ring with a chlorine atom attached to the second carbon. 2-chloro-5,6,7,8-tetrahydroquinoline is used in the synthesis of various pharmaceuticals and agrochemicals due to its versatile chemical reactivity and potential biological activity. It is also used as a building block in the production of dyes and other fine chemicals. Additionally, 2-chloro-5,6,7,8-tetrahydroquinoline has been studied for its potential use in the treatment of various diseases and conditions, making it an important compound in the field of medicinal chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 21172-88-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,1,1,7 and 2 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 21172-88:
(7*2)+(6*1)+(5*1)+(4*7)+(3*2)+(2*8)+(1*8)=83
83 % 10 = 3
So 21172-88-3 is a valid CAS Registry Number.
21172-88-3Relevant articles and documents
Large-Scale Synthesis of 2-Chlorotetrahydroquinoline and 2-Chlorotetrahydroquinolin-8-one
Zong, Zhijian,Wu, Ke,Jin, Liqun,Sun, Nan,Hu, Baoxiang,Shen, Zhenlu,Hu, Xinquan
, p. 3675 - 3683 (2020)
An efficient large-scale preparation of 2-chlorotetrahydroquinoline with cyclohexanone and benzylamine as starting materials was developed and well optimized, in which benzyl-protected enamide was successfully cyclized and benzyl group was directly removed under Vilsmeier conditions. Azeotropic distillation provided 264 g of 2-chlorotetrahydroquinoline (79%) on a 2 mol scale of reaction without intermediate isolation. The downstream product 2-chlorotetrahydroquinolin-8-one was acquired through Boekelheide rearrangement, hydrolysis of acetate via NaBH 4reduction, and Anelli oxidation. With the developed procedure, the intermediates were not necessary to be isolated and 2-chlorotetrahydroquinolin-8-one was conveniently obtained with solvent slurry in 65% overall isolated yield in a four-step sequence.
