1308732-67-3

Basic information

• Product Name: 1-benzyl-5-methyl-3-(2-oxo-2-phenylethyl)indolin-2-one
• Synonyms: 1-benzyl-5-methyl-3-(2-oxo-2-phenylethyl)indolin-2-one
• CAS NO: 1308732-67-3
• Molecular Weight: 355.436
• Mol File: 1308732-67-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-benzyl-5-methyl-3-(2-oxo-2-phenylethyl)indolin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-5-methyl-3-(2-oxo-2-phenylethyl)indolin-2-one(1308732-67-3)
• EPA Substance Registry System: 1-benzyl-5-methyl-3-(2-oxo-2-phenylethyl)indolin-2-one(1308732-67-3)

Safety Data

• Hazardous Substances Data: 1308732-67-3(Hazardous Substances Data)

Upstream product

• 1446104-61-5 1-benzyl-3-diazo-5-methyl-2-oxoindole 
• 614-47-1 1,3-diphenyl-propen-3-one 
• 100-39-0 benzyl bromide 
• 1308732-38-8 (E)-1-benzyl-5-methyl-3-(2-oxo-2-phenylethylidene)indolin-2-one 
• 608-05-9 5-methyl-indole-2,3-dione 
• 99448-75-6 1-benzyl-5-methylindoline-2,3-dione 

Relevant articles and documents

BF3·OEt2catalyzed chemoselective CC bond cleavage of α,β-enones: An unexpected synthesis of 3-alkylated oxindoles and spiro-indolooxiranes

A BF3·OEt2 catalyzed highly chemoselective formal CC double bond cleavage reaction of α,β-enones with diazoamides for the synthesis of 3-alkylated oxindoles is developed. Boron trifluoride etherate is found to be an effective catalyst for the chemoselective Cα-Cβ cleavage of enones to obtain 3-alkylated oxindoles. The product formation indicates a selective β-carbon elimination pathway of α,β-enones using the inexpensive BF3·OEt2 as a catalyst, transition metal-free conditions, an open-air environment, good functional tolerance and broad substrate scope. The synthetic utility of this protocol is highlighted by synthesizing spiro-indolooxiranes.