1446104-61-5Relevant articles and documents
Copper(II)-Catalyzed Domino Synthesis of Indolo[3,2- c]quinolinones via Selective Carbonyl Migration
Arunprasath, Dhanarajan,Sekar, Govindasamy
supporting information, p. 867 - 871 (2019/05/16)
A Cu(II)-catalyzed domino process involving the carbene N-H insertion, intramolecular aldol-type trapping and unprecedented ring-expansion of oxindole core through C3-selective 1,2-carbonyl migration is described for the synthesis of indolo[3,2-c]quinolinones. This tetracyclic core, having an all-carbon quaternary center, was efficiently synthesized in high yields from amines and 3-diazo-oxindoles. Mechanistic studies revealed that this reaction proceeds via a stepwise pathway and the involvement of the synergistic catalysis between Lewis acidic copper and hidden Br?nsted acidity of in-situ-formed TfOH traces.
One-Pot Tandem Diastereoselective and Enantioselective Synthesis of Functionalized Oxindole-Fused Spiropyrazolidine Frameworks
Mei, Liang-Yong,Tang, Xiang-Ying,Shi, Min
, p. 13136 - 13142 (2016/02/19)
A highly efficient palladium(0)-catalyzed asymmetric [3+2] cycloaddition using 3-diazooxindoles serving as dipolarophiles affords functionalized pyrazolidine derivatives in an atom-economical way. In addition, by trapping the pyrazolidine derivatives with maleimides, the corresponding spiropyrazolidine oxindoles containing multiple stereogenic centers have been obtained in high yields along with moderate to good levels of diastereoselectivity and enantioselectivity under mild conditions. Thus, a novel three-component one-pot tandem reaction has been developed.
