130944-47-7Relevant articles and documents
Divergent Supramolecular Gelation of Backbone Modified Short Hybrid δ-Peptides
Reja, Rahi M.,Patel, Rajat,Kumar, Vivek,Jha, Anjali,Gopi, Hosahudya N.
, p. 1254 - 1262 (2019)
The ordered supramolecular assemblies of short peptides have been recently gaining momentum due to their widespread applications in biology and materials sciences. In contrast to the α-peptides, limited success has been achieved from the backbone modified
Kinetic deconjugation: A gateway to the synthesis of Xxx-Gly (E)-alkene dipeptide isosteres
Proteau-Gagné, Arnaud,Nadon, Jean-Franois,Bernard, Sylvain,Guérin, Brigitte,Gendron, Louis,Dory, Yves L.
supporting information; experimental part, p. 6603 - 6605 (2012/02/03)
A new method for the preparation of Xxx-Gly (E)-alkene dipeptide isosteres (EADIs), using LDA deprotonation followed by 1 N HCl quench, was explored. The method, named kinetic deconjugation, enabled the synthesis of Tyr-Gly, Gly-Gly, Ser-Gly, Pro-Gly, and
Synthesis and γ-secretase activity of APP substrate-based hydroxyethylene dipeptide isosteres
Nadin, Alan,Owens, Andrew P.,Castro, José L.,Harrison, Timothy,Shearman, Mark S.
, p. 37 - 41 (2007/10/03)
Two new APP substrate-based hydroxyethylene isosteres (AT and VI) were prepared and their dipeptide conjugates shown not to inhibit the γ-secretase-mediated formation of either Aβ1-40 or Aβ1-42. The FG isostere and a des-hydroxy hydroxyethylene isostere a