1309944-45-3

Basic information

• Product Name: C₂₃H₁₈F₂N₂
• Synonyms: C₂₃H₁₈F₂N₂
• CAS NO: 1309944-45-3
• Molecular Weight: 360.406
• Mol File: 1309944-45-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₃H₁₈F₂N₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₃H₁₈F₂N₂(1309944-45-3)
• EPA Substance Registry System: C₂₃H₁₈F₂N₂(1309944-45-3)

Safety Data

• Hazardous Substances Data: 1309944-45-3(Hazardous Substances Data)

Upstream product

• 459-57-4 4-fluorobenzaldehyde 
• 33386-21-9 (1E,4E)-1,5-bis(4-fluorophenyl)penta-1,4-dien-3-one 
• 100-63-0 phenylhydrazine 

Relevant articles and documents

Dibenzylideneacetone analogues as novel Plasmodium falciparum inhibitors

A series of dibenzylideneacetones (A1-A12) and some of their pyrazolines (B1-B4) were synthesized and evaluated in vitro for blood stage antiplasmodial properties in Plasmodium falciparum culture using SYBR-green-I fluorescence assay. The compound (1E, 4E)-1,5-bis(3,4-dimethoxyphenyl)penta-1,4-dien-3-one (A9) was found to be the most active with IC50 of 1.97 μM against chloroquine-sensitive strain (3D7) and 1.69 μM against chloroquine-resistant field isolate (RKL9). The MTT based cytotoxicity assay on HeLa cell line has confirmed that A9 is selective in its action against malaria parasite (with a therapeutic index of 166). Our results revealed that these compounds exhibited promising antiplasmodial activities which can be further explored as potential leads for the development of cheaper, safe, effective and potent drugs against chloroquine-resistant malarial parasites.