131202-40-9Relevant articles and documents
Synthesis of chiral α-benzyl-β2-hydroxy carboxylic acids through iridium-catalyzed asymmetric hydrogenation of α- oxymethylcinnamic acids
Li, Ze-Yu,Song, Song,Zhu, Shou-Fei,Guo, Na,Wang, Li-Xin,Zhou, Qi-Lin
supporting information, p. 783 - 787 (2014/10/16)
An asymmetric hydrogenation of α-oxymethylcinnamic acids was developed by using chiral spiro phosphine-oxazoline/iridium complexes as catalysts to prepare β2-hydroxycarboxylic acids with high reactivity (TON up to 2000) and excellent enantioselectivity (up to 99.5% ee). By using this highly efficient asymmetric hydrogenation as a key step, a concise total synthesis of natural product homoisoflavone (S)-(+)-4 was accomplished. An asymmetric hydrogenation of α-oxymethylcinnamic acids was developed to prepare β2-hydroxycarboxylic acids with high reactivity (TON up to 2000) and excellent enantioselectivity (up to 99.5% ee), which was applied to a concise total synthesis of a natural product homoisoflavone. Copyright
Synthesis and Structure of (E)-3-Phenylmethylene-2-oxetanone: Comments on the Stability of Methylene β-Lactones
Campi, Eva M.,Dyall, Kenneth,Fallon, Gary,Jackson, W. Roy,Perlmutter, Patrick,Smallridge, Andrew J.
, p. 855 - 856 (2007/10/02)
A route to stereospecifically (E)-substituted methylene-2-oxetanones is exemplified by the preparation of the phenyl derivative 4, whose structure has been confirmed by a single crystal X-ray structure determination.The relative stability of the parent compound, 3-methylene-2-oxetanone (5) has been compared with that of the well-known 4-methylene-2-oxetanone (6) (ketene dimer), by use of calculations involving Gaussian 82 programs.
