13128-74-0Relevant articles and documents
Synthesis of 1,3-Cycloalkadienes from Cycloalkenes: Unprecedented Reactivity of Oxoammonium Salts
Nagasawa, Shota,Sasano, Yusuke,Iwabuchi, Yoshiharu
, p. 13189 - 13194 (2016/10/30)
Few methods allow for the direct conversion of cycloalkenes into cycloalkadienes with high chemo- and regioselectivity. Herein, we report a convenient one-pot process for this transformation that involves the unprecedented N-preferential group transfer of N-oxoammonium salts to cycloalkenes, followed by Cope elimination, to afford cycloalkadienes at room temperature and pressure.
Expedient enantiospecific synthesis of RP 73613: A new selective non-peptide NK1 antagonist
Daubie, Christophe,Mutti, Stephane
, p. 7743 - 7744 (2007/10/03)
The synthesis of RP 73613 was achieved in 13 steps with an overall yield of 12%. The strategy was based on a [3 + 2] azomethine ylid dipolar cycloaddition to generate the bicyclic framework and the asymmetric was introduced by resolution.