1313516-26-5

Basic information

• Product Name: (S)-3-(6-acetylnaphthalen-2-ylamino)-2-aminopropanoic acid
• CAS NO: 1313516-26-5
• Molecular Weight: 272.304
• Mol File: 1313516-26-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (S)-3-(6-acetylnaphthalen-2-ylamino)-2-aminopropanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-(6-acetylnaphthalen-2-ylamino)-2-aminopropanoic acid(1313516-26-5)
• EPA Substance Registry System: (S)-3-(6-acetylnaphthalen-2-ylamino)-2-aminopropanoic acid(1313516-26-5)

Safety Data

• Hazardous Substances Data: 1313516-26-5(Hazardous Substances Data)

Usage

Uses

L-ANAP is a fluorescent unnatural amino acid (UAAs) used to provide unique advantages for imaging biological processes.

Upstream product

• 15231-91-1 6-bromo-naphthalen-2-ol 
• 1313516-29-8 N-tert-butoxycarbonyl-6-acetyl-2-naphthylamine 
• 1313516-30-1 L-3-(6-acetyl-2-naphthylamino)-2-aminopropionic acid methyl ester 
• 1590-25-6 1-(6-bromonaphthalen-2-yl)ethanone 
• 10441-41-5 1-(6-hydroxy-2-naphthyl)ethan-1-one 
• 7470-88-4 1-(6-aminonaphthalen-2-yl)ethanone 
• 151600-02-1 6-bromo-2-naphthalenyl trifluoromethanesulfonate 
• 580-13-2 2-bromonaphthalene 

Relevant articles and documents

Site-specific fluorescence spectrum detection and characterization of hASIC1a channels upon toxin mambalgin-1 binding in live mammalian cells

The synthesis of fluorescent unnatural amino-acid Anap was optimized and the Anap was incorporated into four sites in an acid-pocket or a transmembrane region of human acid-sensing ion channel-1a (hASIC1a). Combinational Anap fluorescence spectra and patc

Enantiospecific synthesis of genetically encodable fluorescent unnatural amino acid l-3-(6-acetylnaphthalen-2-ylamino)-2-aminopropanoic acid

Fluorescent unnatural amino acids (UAAs), when genetically incorporated into proteins, can provide unique advantages for imaging biological processes in vivo. Synthesis of optically pure l-enantiomer of fluorescent UAAs is crucial for their effective application in live cells. An efficient six-step synthesis of l-3-(6-acetylnaphthalen-2-ylamino)-2-aminopropanoic acid (l-Anap), a genetically encodable and polarity-sensitive fluorescent UAA, has been developed. The synthesis takes advantage of a high-yield and enantiospecific Fukuyama-Mitsunobu reaction as the key transformation.