13143-13-0

Basic information

• Product Name: N-benzyl-N’-(2-methylphenyl)urea
• Synonyms: N-benzyl-N’-(2-methylphenyl)urea
• CAS NO: 13143-13-0
• Molecular Weight: 240.305
• Mol File: 13143-13-0.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: N-benzyl-N’-(2-methylphenyl)urea(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzyl-N’-(2-methylphenyl)urea(13143-13-0)
• EPA Substance Registry System: N-benzyl-N’-(2-methylphenyl)urea(13143-13-0)

Safety Data

• Hazardous Substances Data: 13143-13-0(Hazardous Substances Data)

Upstream product

• 40288-37-7 N-benzyl-N'-(2-methylphenyl)thiourea 
• 64-10-8 phenyl carbamate 
• 100-51-6 benzyl alcohol 
• 406190-09-8 N-(o-tolyl)-oxamic acid 
• 100-46-9 benzylamine 
• 615-37-2 ortho-methylphenyl iodide 
• 67-66-3 chloroform 
• 538-32-9 benzylurea 
• 95-46-5 2-methylphenyl bromide 
• 614-68-6 2-tolyl isocyanate 

Downstream Products

• 944338-76-5 1-benzyl-1,3-dimethyl-3-o-tolylurea 
• 614-77-7 N-(2-methylphenyl)urea 
• 1345041-60-2 C₂₂H₂₆N₂O₃ 
• 128253-52-1 C₁₅H₁₅N₃O₂ 
• 128253-54-3 C₁₅H₁₅N₃O₂ 

Relevant articles and documents

Photocatalyzed synthesis of unsymmetrical ureas via the oxidative decarboxylation of oxamic acids with PANI-g-C3N4-TiO2 composite under visible light

The synthesis of unsymmetrical ureas via the photocatalyzed oxidative decarboxylation of oxamic acids has been developed. The carbamoyl radicals were generated from oxamic acids in the presence of a hypervalent iodine reagent and the PANI(Polyaniline)-g-C3N4-TiO2 composite under visible light irradiation. The radicals were converted in situ into the corresponding isocyanates, which were then trapped by amines to afford the corresponding products in moderate to good yields. This protocol avoided the direct use of environmentally unfriendly isocyanates and a series of substrates were tolerated. Moreover, the photocatalyst could be readily recovered by simple filtration and be reused for several runs with only a slight decrease in the catalytic activity.

A synthetic N, N '-di-substituted ureas method

The invention discloses a method for synthesizing N,N'-disubstituent urea. The method comprises the following steps: adding N-substituent urea, a metal iridium, rhodium or ruthenium complex catalyst, an alkali, a compound alcohol and a solvent (or no solvent) to a reaction container; reacting at 90-130 DEG C for a plurality of hours and cooling the reaction mixture to room temperature; carrying out rotary evaporation to remove the solvent, and then separating through a column, so as to obtain a target compound. Compared with the prior art, N,N'-disubstituent urea which is obtained by regional selective alkylation reaction between commercial or easily synthesized N-substituent urea and the alcohol reflects and displays three significant advantages: 1) the alcohol which is nearly non-toxic is utilized as an alkylating reagent; 2) just water is generated as a by-product in the reaction, and harm to environment is not generated; 3) reaction atom economy is high. Therefore, the reaction accords with the requirements of green chemistry, and has a broad development prospect.

The use of aqueous potassium dichloroiodate for the synthesis of ureas

We report a straightforward and efficient reaction protocol for the syntheses of substituted ureas via treatment of thioureas with aqueous potassium dichloroiodate (KICl2). By tuning the reaction condition, thioureas bearing activated N-aryl substituents may undergo either selective oxidation or sequential oxidation and iodination, forming iodoaryl ureas in the latter case.