131468-32-1

Basic information

• Product Name: 6-chloro-N²,N⁴-bis(4-fluorophenyl)-1,3,5-triazine-2,4-diamine
• Synonyms: 6-chloro-N²,N⁴-bis(4-fluorophenyl)-1,3,5-triazine-2,4-diamine
• CAS NO: 131468-32-1
• Molecular Weight: 333.728
• Mol File: 131468-32-1.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: 6-chloro-N²,N⁴-bis(4-fluorophenyl)-1,3,5-triazine-2,4-diamine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloro-N²,N⁴-bis(4-fluorophenyl)-1,3,5-triazine-2,4-diamine(131468-32-1)
• EPA Substance Registry System: 6-chloro-N²,N⁴-bis(4-fluorophenyl)-1,3,5-triazine-2,4-diamine(131468-32-1)

Safety Data

• Hazardous Substances Data: 131468-32-1(Hazardous Substances Data)

Upstream product

• 108-77-0 1,3,5-trichloro-2,4,6-triazine 
• 371-40-4 4-fluoroaniline 
• 131468-33-2 (4,6-dichloro-[1,3,5]triazin-2-yl)-(4-fluorophenyl)-amine 

Downstream Products

• 1620172-82-8 5-(4-chloro-phenyl)-3-phenyl-4,5-dihydro-pyrazole-1-carbothioic acid [4,6-bis-(4-fluorophenylamino)-[1,3,5]triazin-2-yl]-amide 
• 1620172-81-7 5-(2-chloro-phenyl)-3-phenyl-4,5-dihydro-pyrazole-1-carbothioic acid [4,6-bis-(4-fluorophenylamino)-[1,3,5]triazin-2-yl]-amide 
• 1620172-80-6 5-(4-nitro-phenyl)-3-phenyl-4,5-dihydro-pyrazole-1-carbothioic acid [4,6-bis-(4-fluorophenylamino)-[1,3,5]triazin-2-yl]-amide 
• 1620172-79-3 3,5-diphenyl-4,5-dihydro-pyrazole-1-carbothioic acid [4,6-bis-(4-fluoro-phenylamino)-[1,3,5]triazin-2-yl]-amide 
• 1620172-78-2 3,5-diphenyl-4,5-dihydro-pyrazole-1-carbothioic acid [4,6-bis-(4-fluoro-phenylamino)-[1,3,5]triazin-2-yl]-amide 
• 1408322-22-4 C₂₈H₂₄F₂N₁₀S₂ 
• 1258254-43-1 C₂₄H₁₆F₂N₈O₂S 
• 1246834-49-0 N,N'-bis(4-fluorophenyl)-N-(pyrimidin-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine 
• 505062-28-2 C₂₃H₁₈F₂N₆O 

Relevant articles and documents

Triaminotriazine DNA helicase inhibitors with antibacterial activity

Screening of a chemical library in a DNA helicase assay involving the Pseudomonas aeruginosa DnaB helicase provided a triaminotriazine inhibitor with good antibacterial activity but associated cytotoxicity toward mammalian cells. Synthesis of analogs provided a few inhibitors that retained antibacterial activity and demonstrated a significant reduction in cytotoxicity. The impact of serum and initial investigations toward a mode of action highlight several features of this class of compounds as antibacterials.

Optimization of the pharmacokinetic properties of potent anti-trypanosomal triazine derivatives

Human African trypanosomiasis is causing thousands of deaths every year in the rural areas of sub-saharan Africa. There is a high unmet medical need since the approved drugs are poorly efficacious, show considerable toxicity and are not easy to administer

Structure-guided discovery of 1,3,5-triazine-pyrazole conjugates as antibacterial and antibiofilm agent against pathogens causing human diseases with favorable metabolic fate

Impressed by the exceptional antibacterial activity exhibited by our earlier designed molecules originating from 1,3,5-triazine, the present study was undertaken to synthesize a novel series of 1,3,5-triazine-pyrazole conjugates to bring diversity around the core skeleton. The target analogues showed potent antibacterial activity against tested Gram-positive and Gram-negative microorganisms. The toxicity and metabolic site prediction studies were also held out to set an effective lead candidate for the future antibacterial drug discovery initiatives.