1314881-68-9Relevant articles and documents
Inhibition of the cellular function of perforin by 1-amino-2,4- dicyanopyrido[1,2-a]benzimidazoles
Lyons, Dani M.,Huttunen, Kristiina M.,Browne, Kylie A.,Ciccone, Annette,Trapani, Joseph A.,Denny, William A.,Spicer, Julie A.
, p. 4091 - 4100 (2011/08/09)
A high throughput screen showed the ability of a 1-amino-2,4- dicyanopyrido[1,2-a]benzimidazole analogue to directly inhibit the lytic activity of the pore-forming protein perforin. A series of analogues were prepared to study structure-activity relations