135857-20-4

Basic information

• Product Name: 2-(4-FORMYLPHENOXY)ACETAMIDE
• Synonyms: ART-CHEM-BB B000277;2-(4-FORMYLPHENOXY)ACETAMIDE;AKOS B000277;2-(4-formylphenoxy)acetamide(SALTDATA: FREE);2-(4-methanoylphenoxy)ethanamide
• CAS NO: 135857-20-4
• Molecular Formula: C₉H₉NO₃
• Molecular Weight: 179.17
• Mol File: 135857-20-4.mol
• Article Data: 7

Chemical Properties

• Melting Point: 135-137 °C(Solv: water (7732-18-5))
• Boiling Point: 435.6°C at 760 mmHg
• Flash Point: 268.9°C
• Appearance: /
• Density: 1.258g/cm³
• Vapor Pressure: 8.63E-08mmHg at 25°C
• Refractive Index: 1.587
• Storage Temp.: 2-8°C
• PKA: 15.21±0.40(Predicted)
• CAS DataBase Reference: 2-(4-FORMYLPHENOXY)ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-FORMYLPHENOXY)ACETAMIDE(135857-20-4)
• EPA Substance Registry System: 2-(4-FORMYLPHENOXY)ACETAMIDE(135857-20-4)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 135857-20-4(Hazardous Substances Data)

Usage

General Description

2-(4-Formylphenoxy)acetamide is a chemical compound with the molecular formula C10H9NO3. It is a white to light brown solid that is commonly used in organic synthesis and pharmaceutical research. 2-(4-FORMYLPHENOXY)ACETAMIDE is a formylated derivative of phenol and contains an amide group, making it a part of the acetamide family. It is often used as a building block in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds. Additionally, it has been studied for its potential medicinal properties, including its ability to inhibit certain enzymes and its potential as a drug candidate for various conditions. Due to its versatility and potential pharmacological uses, 2-(4-Formylphenoxy)acetamide is of interest in the fields of chemistry and medicine.

InChI:InChI=1/C9H9NO3/c10-9(12)6-13-8-3-1-7(5-11)2-4-8/h1-5H,6H2,(H2,10,12)

Upstream product

• 123-08-0 4-hydroxy-benzaldehyde 
• 79-07-2 Chloroacetamide 
• 144-48-9 iodacetamide 
• 683-57-8 bromo-acetic acid amide 

Downstream Products

• 371956-62-6 2-amino-4-(4-carbamoylmethoxy)phenyl-3-cyano-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-benzo[b]pyran 
• 902745-30-6 2-(4-carbamoylmethoxy-benzylidene)-malonic acid 
• 873811-55-3 3-(4-carbamoylmethoxy-phenyl)-acrylic acid 
• 1044870-60-1 2-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenoxy)acetamide 
• 930552-50-4 2-(4-((5-chloro-2-oxoindolin-3-ylidene)methyl)phenoxy)acetamide 
• 1100350-28-4 C₂₀H₁₇N₃O₃S 
• 519018-81-6 (E,Z)-2-(4-(2-(1H-benzo[d]imidazol-2-yl)-2-cyanovinyl)phenoxy)acetamide 
• 1314881-68-9 (E,Z)-2-(4-(2-(4-chloro-1H-benzo[d]imidazol-2-yl)-2-cyanovinyl)phenoxy)acetamide 
• 1314881-69-0 (E,Z)-2-(4-(2-cyano-2-(4-methoxy-1H-benzo[d]imidazol-2-yl)vinyl)phenoxy)acetamide 
• 1314881-70-3 (E,Z)-2-(4-(2-cyano-2-(4,5-dimethyl-1H-benzo[d]imidazol-2-yl)vinyl)phenoxy)acetamide 
• 471921-91-2 2-(4-(2-cyano-2-(5,6-dimethyl-1H-benzo[d]imidazol-2-yl)vinyl)phenoxy)acetamide 
• 335208-79-2 2-[4-(1-amino-2,4-dicyanopyrido[1,2-a]benzimidazol-3-yl)phenoxy]acetamide 
• 1314881-62-3 2-(4-(1-amino-2,4-dicyano-6-methylbenzo[4,5]imidazo[1,2-a]pyridin-3-yl)phenoxy)acetamide 
• 1314881-63-4 2-(4-(1-amino-6-chloro-2,4-dicyanobenzo[4,5]imidazo[1,2-a]pyridin-3-yl)phenoxy)acetamide 

Relevant articles and documents

A process for the preparation of intermediates palestinian multi-past fragrance acetate

The invention discloses a method for preparing a bazedoxifene acetate intermediate. The preparation method comprises the following steps: 1, condensing 4-hydroxybenzaldehyde S01 and alkylate S02 to prepare a 4-formyl phenoxy derivative M01; 2, performing

Synthesis and biological evaluation of 2-Phenoxyacetamide analogues, a novel class of potent and selective monoamine oxidase inhibitors

Monoamine oxidases (EC 1.4.3.4; MAOs), a family of FAD-containing enzymes, is an important target for antidepressant drugs. In this paper, a series of 2-phenoxyacetamide analogues were synthesized, and their inhibitory potency towards monoamine oxidases A (MAO-A) and B (MAO-B) were evaluated using enzyme and cancer cell lysate. 2-(4-Methoxyphenoxy)acetamide (compound 12) (SI = 245) and (2-(4-((prop-2- ynylimino)methyl)phenoxy)acetamide (compound 21) (IC50MAO-A = 0.018 μM, IC50MAO-B = 0.07 μM) were successfully identified as the most specific MAO-A inhibitor, and the most potent MAO-A/-B inhibitor, respectively. The inhibitory activities of these two compounds in living cells were also further evaluated utilizing HepG2 and SHSY-5Y cell lysates.

Inhibition of γ-secretase by the CK1 inhibitor IC261 does not depend on CK1δ

CK1 and γ-secretase are interesting targets for therapeutic intervention in the treatment of cancer and Alzheimer's disease. The CK1 inhibitor IC261 was reported to inhibit γ-secretase activity. The question is: Does CK1 inhibition directly influence γ-se