1316224-74-4

Basic information

• Product Name: C₁₉H₁₆O₆
• Synonyms: C₁₉H₁₆O₆
• CAS NO: 1316224-74-4
• Molecular Weight: 340.332
• Mol File: 1316224-74-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₉H₁₆O₆(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₉H₁₆O₆(1316224-74-4)
• EPA Substance Registry System: C₁₉H₁₆O₆(1316224-74-4)

Safety Data

• Hazardous Substances Data: 1316224-74-4(Hazardous Substances Data)

Upstream product

• 76172-68-4 3-(4-methoxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one 
• 18065-05-9 1-[2,4-bis(benzyloxy)-6-hydroxyphenyl]ethanone 
• 480-66-0 2,4,6-trihydroxyacetophenone 
• 74-88-4 methyl iodide 
• 65490-09-7 2'-hydroxy-4',6'-bis(methoxymethoxy)acetophenone 

Downstream Products

• 74805-89-3 5,7-dihydroxy-3-(4-methoxybenzyl)-6,8-dimethyl-4H-chromen-4-one 

Relevant articles and documents

An Efficient Regioselective Synthesis of 8-Formylhomoisoflavonoids with Neuroprotective Activity by Enhancing Autophagy

6-Formylisoophiopogonone B (7a) and 8-formylophiopogonone B (7b), two natural products isolated fromOphiopogonjaponicus, represent a subgroup of rare 6/8-formyl/methyl-homoisoflavonoid skeletons. Herein we report an efficient method for the synthesis of these formyl/methyl-homoisoflavonoids. The synthesized compounds were evaluated for their neuroprotective effects on the MPP+-induced SH-SY5Y cell injury model and showed marked activity. Exploration of the neuroprotective mechanisms of compound7bled to an increased expression of autophagy marker LC3-II and down-regulation of autophagy substrate p62/SQSTM1. Molecular docking studies showed that7bmay prevent the inhibition of the classic PI3K-AKT-mTOR signaling pathway by interfering with the human HSP90AA1.