74805-89-3

Basic information

• Product Name: Methylophiopogonone B
• Synonyms: Methylophiopogonone B
• CAS NO: 74805-89-3
• Molecular Formula: C₁₉H₁₈O₅
• Molecular Weight: 326.34322
• Mol File: 74805-89-3.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Methylophiopogonone B(CAS DataBase Reference)
• NIST Chemistry Reference: Methylophiopogonone B(74805-89-3)
• EPA Substance Registry System: Methylophiopogonone B(74805-89-3)

Safety Data

• Hazardous Substances Data: 74805-89-3(Hazardous Substances Data)

Usage

General Description

Methylophiopogonone B is a natural chemical compound isolated from the roots of Ophiopogon jaburan. It has been found to possess various pharmacological activities, including anti-inflammatory, anti-allergic, and antioxidant properties. Methylophiopogonone B has been studied for its potential as a therapeutic agent for conditions such as asthma, atopic dermatitis, and other inflammatory diseases. Its antioxidant activity also suggests potential uses in the prevention and treatment of conditions related to oxidative stress, such as cardiovascular disease and aging-related disorders. Further research into the pharmacological effects and potential medical applications of Methylophiopogonone B is ongoing.

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Downstream Products

• 74805-86-0 methylophiopogonone B monomethyl ether 
• 74805-84-8 5-Hydroxy-7-methoxy-3-(4-methoxy-benzyl)-6,8-dimethyl-chroman-4-one 

Relevant articles and documents

An Efficient Regioselective Synthesis of 8-Formylhomoisoflavonoids with Neuroprotective Activity by Enhancing Autophagy

6-Formylisoophiopogonone B (7a) and 8-formylophiopogonone B (7b), two natural products isolated fromOphiopogonjaponicus, represent a subgroup of rare 6/8-formyl/methyl-homoisoflavonoid skeletons. Herein we report an efficient method for the synthesis of these formyl/methyl-homoisoflavonoids. The synthesized compounds were evaluated for their neuroprotective effects on the MPP+-induced SH-SY5Y cell injury model and showed marked activity. Exploration of the neuroprotective mechanisms of compound7bled to an increased expression of autophagy marker LC3-II and down-regulation of autophagy substrate p62/SQSTM1. Molecular docking studies showed that7bmay prevent the inhibition of the classic PI3K-AKT-mTOR signaling pathway by interfering with the human HSP90AA1.