131669-28-8Relevant articles and documents
Generation of α-amino acid homoenolate equivalents. Synthesis of 3-substituted prolines
Moss, William O.,Bradbury, Roben H.,Hales, Neil J.,Gallagher, Timothy
, p. 5653 - 5656 (2007/10/02)
Deprotonation of the N-protected aminoketene-S,S-acetal (6) and reaction of allylic anion (7) with electrophiles leads to adducts (8) which have been converted to 3-substituted prolines (11). Conformationally constrained variants (11d) and (11e) of aspartic and glutamic acid have been prepared.