1318768-17-0

Basic information

• Product Name: N-(tert-butyloxycarbonyl)-2-(pyridin-2-yl)aniline
• Synonyms: N-(tert-butyloxycarbonyl)-2-(pyridin-2-yl)aniline
• CAS NO: 1318768-17-0
• Molecular Weight: 270.331
• Mol File: 1318768-17-0.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: N-(tert-butyloxycarbonyl)-2-(pyridin-2-yl)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: N-(tert-butyloxycarbonyl)-2-(pyridin-2-yl)aniline(1318768-17-0)
• EPA Substance Registry System: N-(tert-butyloxycarbonyl)-2-(pyridin-2-yl)aniline(1318768-17-0)

Safety Data

• Hazardous Substances Data: 1318768-17-0(Hazardous Substances Data)

Upstream product

• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 99879-59-1 (tert-butoxycarbonyl)(pyridin-1-ium-1-yl)amide 
• 36016-38-3 tert-Butyl N-hydroxycarbamate 
• 1008-89-5 2-phenylpyridine 
• 1440756-11-5 tert-butyl (2,4,6-trichlorobenzoyl)oxycarbamate 
• 109-04-6 2-bromo-pyridine 
• 98-80-6 phenylboronic acid 
• 1613027-57-8 tert-butyl (4-t-butylbenzoyl)oxycarbamate 
• 1310366-45-0 tert-butyl 2-phenylacetoxycarbamate 
• 35657-40-0 tert-butyl (pivaloyloxy)carbamate 
• 99768-83-9 (acetyloxy)carbamic acid 1,1-dimethyl ethyl ester 
• 1613027-54-5 methyl 4-[{(tert-butoxycarbonyl)amino}oxycarbonyl]benzoate 
• 35657-41-1 tert-butyl [(4-nitrobenzoyl)oxy]carbamate. 
• 1613027-55-6 tert-butyl (3-nitrobenzoyl)oxycarbamate 

Downstream Products

• 29528-30-1 2-(2-pyridyl)aniline 

Relevant articles and documents

Sulfated tungstate: A highly efficient, recyclable and ecofriendly catalyst for chemoselective N-tert butyloxycarbonylation of amines under the solvent-free conditions

Sulfated tungstate catalyzed an efficient and ecofriendly protocol has been described for the chemoselective N-tert-butyloxycarbonylation of amines under the solvent-free conditions at room temperature. The variety of functionalized aliphatic, aromatic and heteroaromatic amines efficiently undergoes the N-tert-butyloxycarbonylation under the developed protocol. The aminoalcohol, aminophenol, aminoester as well as various chiral amines underwent the chemoselective N-Boc protection under the optimized reaction condition. The rapid reaction rate, mild conditions, very good functional group tolerance, excellent yield, solvent-free, easy recovery products and excellent catalyst recyclability are the advantages of this protocol. This makes the protocol feasible, economical and environmentally benign.

Thiamine hydrochloride as a recyclable organocatalyst for the efficient and chemoselective N-tert-butyloxycarbonylation of amines

Thiamin hydrochloride promoted highly efficient and ecofriendly approach has been described for the chemoselective N-tert-butyloxycarbonylation of amines under solvent-free conditions at ambient temperature. The demonstrated approach has been applicable for the N-Boc protection of variety of aliphatic, aryl, heteroaryl amines. The chemoselective protection of amino group occurs in chiral amines and amino alcohol without racemization in high yield. Thiamin hydrochloride is stable, economical, easy to handle and environmentally friendly.

Rhodium-Catalyzed N-tert-Butoxycarbonyl (Boc) Amination by Directed C H Bond Activation

N-tert-Butoxycarbonyl azide (BocN3) was shown to be an efficient and economic source for the directed introduction of N-Boc protected amino groups into the thiophene and benzene nucleus. Yields for the amination of 2-pyridin-2-ylthiophenes (10 examples) were 52–88%. For the amination of the respective benzenes (10 examples) yields between 54% and 99% were recorded with an improved reactivity observed for substrates that bear an electron-withdrawing group. The reaction was applied to short total syntheses of the indoloquinoline alkaloids quindoline and cryptolepine. The facile removal of the Boc protecting group was the key to the success of the syntheses. The scope of the reaction was extended to a C(sp3) H bond amination and to the amination of 2-phenyloxazoline. For the amination of 2-pyridin-2-ylbenzene a kinetic deuterium isotope effect of 2.0 was determined. (Figure presented.) .