35657-41-1

Basic information

• Product Name: tert-Butyl (4-nitrobenzoyl)oxycarbaMate
• Synonyms: tert-Butyl (4-nitrobenzoyl)oxycarbaMate;[(2-methylpropan-2-yl)oxycarbonylamino] 4-nitrobenzoate
• CAS NO: 35657-41-1
• Molecular Formula: C₁₂H₁₄N₂O₆
• Molecular Weight: 282.24936
• Mol File: 35657-41-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.297g/cm³
• Refractive Index: 1.541
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: tert-Butyl (4-nitrobenzoyl)oxycarbaMate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-Butyl (4-nitrobenzoyl)oxycarbaMate(35657-41-1)
• EPA Substance Registry System: tert-Butyl (4-nitrobenzoyl)oxycarbaMate(35657-41-1)

Safety Data

• Hazardous Substances Data: 35657-41-1(Hazardous Substances Data)

Usage

General Description

Tert-butyl (4-nitrobenzoyl)oxycarbamate is a chemical compound that is primarily used as a reagent in organic synthesis and research. It is known for its ability to protect amino groups in peptides and to control the release of active ingredients in drug delivery systems. The compound consists of a tert-butyl group, a 4-nitrobenzoyl group, and an oxycarbamate group, which contribute to its stability and reactivity. Tert-butyl (4-nitrobenzoyl)oxycarbamate is a versatile chemical with potential applications in the pharmaceutical and biotechnology industries.

InChI:InChI=1/C12H14N2O6/c1-12(2,3)19-11(16)13-20-10(15)8-4-6-9(7-5-8)14(17)18/h4-7H,1-3H3,(H,13,16)

Upstream product

• 1070-19-5 N-(tert-butyloxycarbonyl) azide 
• 36016-38-3 tert-Butyl N-hydroxycarbamate 
• 62-23-7 4-nitro-benzoic acid 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 35657-36-4 O-(4-nitrobenzoyl) hydroxylamine 
• 1318768-17-0 N-(tert-butyloxycarbonyl)-2-(pyridin-2-yl)aniline 
• 18437-63-3 tert-butyl N-(4-nitrophenyl)carbamate 

Relevant articles and documents

Palladium-Catalyzed Decarboxylative Synthesis of Arylamines

A novel approach has been developed for the synthesis of arylamines via the palladium-catalyzed intramolecular decarboxylative coupling (IDC) of aroyloxycarbamates, obtained in situ by reacting aryl carboxylic acids with hydroxycarbamates. The reaction offers facile access to structurally diverse arylamines with the site-specific formation of the C(sp2)-N bond under mild conditions.

Fischer synthesis of isomeric thienopyrrole LHRH antagonists

As part of a structure-activity exploration into LHRH antagonists, structures containing the thieno[2,3-b]pyrrole core were identified as potent antagonists. This letter describes the employment of the Fischer synthesis to access this thienopyrrole and isomeric final compounds.