13190-50-6

Basic information

• Product Name: [p-(dimethylamino)phenyl]lithium
• Synonyms: [p-(dimethylamino)phenyl]lithium;[4-(Dimethylamino)phenyl]lithium;4-(Dimethylamino)phenyllithium;N,N-Dimethyl-4-lithioaniline;Einecs 236-146-9
• CAS NO: 13190-50-6
• Molecular Formula: C₈H₁₀LiN
• Molecular Weight: 127.1127
• EINECS: 236-146-9
• Mol File: 13190-50-6.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: [p-(dimethylamino)phenyl]lithium(CAS DataBase Reference)
• NIST Chemistry Reference: [p-(dimethylamino)phenyl]lithium(13190-50-6)
• EPA Substance Registry System: [p-(dimethylamino)phenyl]lithium(13190-50-6)

Safety Data

• Hazardous Substances Data: 13190-50-6(Hazardous Substances Data)

Usage

Description

[p-(dimethylamino)phenyl]lithium, with the chemical formula C8H11NLi, is an organolithium reagent characterized by a phenyl group with a dimethylamino substitution and a lithium atom attached to the phenyl ring. [p-(dimethylamino)phenyl]lithium is highly reactive and serves as a potent nucleophile and strong base in organic synthesis. Due to its sensitivity to air and moisture, it requires careful handling and is typically stored and manipulated under inert atmospheres or in dry solvents.

Uses

Used in Organic Synthesis:
[p-(dimethylamino)phenyl]lithium is used as a strong base and nucleophile for various organic synthesis applications, including metalation, cross-coupling, and addition reactions. Its high reactivity makes it a valuable tool in constructing complex organic molecules and frameworks.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, [p-(dimethylamino)phenyl]lithium is utilized as a reagent in the synthesis of complex drug molecules. Its ability to participate in various types of reactions allows for the creation of a wide range of pharmaceutical compounds with specific therapeutic properties.
Used in Material Science:
[p-(dimethylamino)phenyl]lithium is also employed in material science for the development of novel materials with unique properties. Its reactivity enables the formation of new bonds and structures that can be tailored for specific applications, such as in the creation of advanced polymers or composites with improved characteristics.
Used in Chemical Research:
In the field of chemical research, [p-(dimethylamino)phenyl]lithium serves as an important reagent for exploring new reaction mechanisms and developing innovative synthetic methods. Its versatility in participating in various types of reactions makes it a valuable tool for researchers looking to push the boundaries of chemical synthesis and understanding.

InChI:InChI=1/C8H10N.Li/c1-9(2)8-6-4-3-5-7-8;/h4-7H,1-2H3;/rC8H10LiN/c1-10(2)8-5-3-7(9)4-6-8/h3-6H,1-2H3

Upstream product

• 586-77-6 4-bromo-N,N-dimethylaniline 
• 109-72-8 n-butyllithium 
• 121-69-7 N,N-dimethyl-aniline 

Downstream Products

• 32564-93-5 4-(isoquinolin-1-yl)-N,N-dimethylaniline 
• 30479-25-5 N,N-dimethyl-4-(8-methyl-quinolin-2-yl)-aniline 
• 66333-77-5 4-(9,10-dihydro-acridin-9-yl)-N,N-dimethyl-aniline 
• 102079-39-0 N,N-dimethyl-4-[4,7]phenanthrolin-3-yl-aniline 
• 110194-67-7 1,3-bis-(4-dimethylamino-phenyl)-propan-2-ol 
• 114554-83-5 1,1-bis-(4-dimethylamino-phenyl)-3,3-dimethyl-butane-1,2,4-triol 
• 70508-11-1 4-benzo[b]arsindol-5-yl-N,N-dimethyl-aniline 
• 94462-46-1 (+/-)-1-<4-Dimethylamino-phenyl>-1-isopropylamino-but-2-en 
• 97725-56-9 (+/-)-1-<4-Dimethylamino-phenyl>-2-methyl-1-propylamino-propan 
• 33384-19-9 4-(4-Dimethylaminophenyl)-2-chlor-3,3-difluor-1-phenyl-cyclobuten 
• 100267-50-3 (+/-)-1-Diaethylamino-2,2-dimethyl-3-<4-dimethylamino-phenyl>-3-propylamino-propan 
• 3112-94-5 N,N-dimethyl-4-(phenylsulfonyl) aniline 
• 77876-37-0 p-Sn{C₆H₄N(CH₃)2}4 
• 14064-16-5 <4-(Dimethylamino)phenyl>trimethylstannan 

Relevant articles and documents

CATALYTIC RADIOFLUORINATION

One aspect of the present invention relates to a method of preparing radio fluorinated substituted alkyl, cycloalkyl, aryl, and alkenyl compounds. In a preferred embodiment, potassium fluoride-18 is used. Another aspect of the invention relates to arylammonium compounds containing fluorine-18 that are useful as imaging agents. In certain embodiments, the ammonium compound is a tetraaryl ammonium salt. Another aspect of the invention relates to arylsulfonium compounds containing fluorine-18 that are useful as imaging agents. In certain embodiments, the sulfonium compound is a triaryl sulfonium salt. Another aspect of the present invention relates to a method of obtaining a positron emission image of a mammal, comprising the steps of administering to a mammal a compound of the invention, and acquiring a positron emission spectrum of the mammal.