32564-93-5

Basic information

• Product Name: 4-(isoquinolin-1-yl)-N,N-dimethylaniline
• Synonyms: 4-(isoquinolin-1-yl)-N,N-dimethylaniline
• CAS NO: 32564-93-5
• Molecular Weight: 248.327
• Mol File: 32564-93-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-(isoquinolin-1-yl)-N,N-dimethylaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(isoquinolin-1-yl)-N,N-dimethylaniline(32564-93-5)
• EPA Substance Registry System: 4-(isoquinolin-1-yl)-N,N-dimethylaniline(32564-93-5)

Safety Data

• Hazardous Substances Data: 32564-93-5(Hazardous Substances Data)

Upstream product

• 119-65-3 isoquinoline 
• 13190-50-6 4-dimethylaminophenyllithium 
• 4702-25-4 2-mercaptoisoquinoline 
• 586-77-6 4-bromo-N,N-dimethylaniline 
• 19493-44-8 1-chloroisoquinoline 
• 28611-39-4 4-(dimethylamino)benzene-boronic acid 

Relevant articles and documents

Synthesis, photophysical, electrochemical and electroluminescence studies of red emitting phosphorescent Ir(III) heteroleptic complexes

Abstract: Five heteroleptic, cyclometalated (C∧N) Iridium(III) complexes of acetylacetone (acac) and 1-phenyl-isoquinoline (piq) derivatives, Ir(acac)(piq)2, Ir(acac)(2,4-difluoro-piq)2, Ir(acac)(4-trifluoromethyl-piq)2, Ir(acac)(4-N,N-dimethyl-piq)2, Ir(acac)(4-acetyl-piq)2, were synthesized and characterized. The (C ∧N ) 2Ir(acac) complexes in toluene showed phosphorescence (λ max= 598 nm to 658 nm) with quantum yields (0.1 to 0.32) and microsecond lifetimes (0.43 to 1.9 μ s). The complexes were non-luminescent in thin films due to self-quenching but luminescent when lightly doped (5%) in a host organic material, 4,4′-Bis(N-carbazolyl)-1,1′-biphenyl (CBP). The HOMO levels determined using cyclic voltammetric oxidation potentials were in the range ?5.48 to ?5.80 eV. Electroluminescence properties and performance of the Ir complexes doped in CBP (active layer) were studied in a multilayer (ITO/F4TCNQ/TPD/doped CBP/BCP/LiF/Al) organic light emitting device (OLED). The electroluminescense (EL) spectra of the device matched with the phosphorescent spectra of the Ir complexes. The turn-on voltage at ～ 4.5 V, maximum brightness of 7600 cd/m 2 and current efficiency of ～ 7.0 cd/A at a brightness of ～ 100 cd/m 2 indicate that these are promising OLED materials. GRAPHICAL ABSTRACT: Synopsis. Heteroleptic, cyclometalated (C∧N) Iridium(III) complexes of acetylacetone (acac) and 1-phenyl-isoquinoline were synthesized and their photophysical, electrochemical and electroluminescence properties were studied. The OLED of Ir complex as emitting material showed turn-on voltage at ～ 4.5 V, maximum brightness of 7600 cd/m 2 and current efficiency of ～ 7.0 cd/A at a brightness of ～ 100 cd/m 2.[Figure not available: see fulltext.].

Imaging agents for detecting neurological disorders

Imaging agents of formula (I) and methods for detecting neurological disorders comprising administering to a patient in need compounds of formula (I) capable of binding to tau proteins and β-amyloid peptides are presented herein. The invention also relates to methods of imaging Aβ and tau aggregates comprising introducing a detectable quantity of pharmaceutical formulation comprising a radiolabeled compound of formula (I) and detecting the labeled compound associated with amyloid deposits and/or tau proteins in a patient. These methods and compositions enable preclinical diagnosis and monitoring progression of AD and other neurological disorders.