1319735-77-7Relevant articles and documents
Design, synthesis and anticonvulsant evaluation of novel 8-substituted-4(3H)-quinazolines
El-Azab, Adel S.,ElTahir, Kamal E. H.
, p. 3785 - 3796 (2013/02/23)
A new series of 8-substituted-4(3H)-quinazoline derivatives were synthesized, evaluated for their anticonvulsant activity against chemically (PTZ, picrotoxin and Strychnine) and electrically (MES) induced seizures and compared with the reference drugs valproate and methaqualone. Acid hydrazide, acetylhydrazine carboxylate and acetylhydrazinecarbodithioate were the most active compounds with relatively low neurotoxicity compared with the standard drugs. The obtained results proved that the mostly active compounds could be useful as a model for future design, adaptation and investigation to construct more active analogues. Springer Science+Business Media, LLC 2011.
Synthesis and anticonvulsant evaluation of some novel 4(3H)-quinazolinones
El-Azab, Adel S.,ElTahir, Kamal E.H.,Attia, Sabry M.
, p. 837 - 848 (2012/08/07)
A series of novel quinazoline derivatives, methaqualone analogs, were synthesized, evaluated for their anticonvulsant activity against electrically and chemically (pentylenetetrazole, picrotoxin, and strychnine) induced seizures and compared with the stan