132127-30-1

Basic information

• Product Name: (3R,4S)-3-<(tert-butyldimethylsilyl)oxy>-4-phenylazetidin-2-one
• Synonyms: (3R,4S)-3-<(tert-butyldimethylsilyl)oxy>-4-phenylazetidin-2-one
• CAS NO: 132127-30-1
• Molecular Weight: 277.439
• Mol File: 132127-30-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (3R,4S)-3-<(tert-butyldimethylsilyl)oxy>-4-phenylazetidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (3R,4S)-3-<(tert-butyldimethylsilyl)oxy>-4-phenylazetidin-2-one(132127-30-1)
• EPA Substance Registry System: (3R,4S)-3-<(tert-butyldimethylsilyl)oxy>-4-phenylazetidin-2-one(132127-30-1)

Safety Data

• Hazardous Substances Data: 132127-30-1(Hazardous Substances Data)

Upstream product

• 17599-61-0 N-benzylidene-1,1,1-trimethylsilanamine 
• 132127-25-4 (1R,2S)-2-Phenyl-1-cyclohexyl t-butyldimethylsilyloxyacetate 
• 1613-90-7 4-methoxy-N-[(E)-phenylmethylidene]aniline 
• 950586-06-8 (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (2R,3S)-2-tert-butyldimethylsiloxy-3-(4-methoxyphenylamino)-3-phenylpropanoate 
• 950586-04-6 (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (2R,3S)-2-hydroxy-3-(4-methoxyphenylamino)-3-phenylpropanoate 
• 880781-88-4 (3R,4S)-3-tert-butyldimethylsiloxy-1-(4-methoxyphenyl)-4-phenylazetidin-2-one 
• 120419-97-8 (E)-N-benzylidene-1,1,1-trimethylsilanamine 
• 132127-26-5 2-O-<<(tert-butyldimethylsilyl)oxy>acetyl>-10-(dicyclohexylsulfamoyl)-D-isoborneol 
• 132127-25-4 (tert-Butyl-dimethyl-silanyloxy)-acetic acid 2-phenyl-cyclohexyl ester 

Downstream Products

• 152089-13-9 (3R,4S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-oxo-4-phenyl-azetidine-1-carboxylic acid tert-butyl ester 
• 132127-34-5 (3R,4S)-3-hydroxy-4-phenylazetidin-2-one 
• 160237-83-2 7-(triethylsilyl)baccatin III 13--(2'R,3'S)-3'-phenylisoserinate> 
• 155399-27-2 7-(triethylsilyl)baccatin III 13- 
• 153695-19-3 N-(4-azidobenzoyl)-N-debenzoyltaxol 
• 133524-70-6 13-(O-2R-hydroxy-3S-amine-phenylpropionyl)-baccatin III 
• 160239-19-0 7-O-(triethylsilyl)baccatrin III 13-O-<(2R,3S)-N-benzoyl-2-O-(tert-butyldimethylsilyl)-3-cyclohexylisoserinate> 
• 160239-18-9 (3R,4S)-1-benzoyl-3-<(tert-butyldimethylsilyl)oxy>-4-cyclohexyl-2-azetidinone 
• 186347-81-9 (3R,4S)-3-(tert-Butyl-dimethyl-silanyloxy)-1-hexanoyl-4-phenyl-azetidin-2-one 
• 160239-17-8 (3R,4S)-3-<(tert-butyldimethylsilyl)oxy>-4-cyclohexyl-2-azetidinone 
• 155399-25-0 (3R,4S)-1-(benzyloxycarbonyl)-3-<(tert-butyldimethylsilyl)oxy>-4-phenyl-2-azetidinone 

Relevant articles and documents

Asymmetric synthesis of 3-amino-2-hydroxyalkanoates by Mannich reaction of menthyl acetate with imines and subsequent oxidation

Lithium amide-assisted Mannich-type reaction of menthyl acetate-derived lithium enolate with PMP-arylaldimines and subsequent in situ oxidation with oxaziridine gave syn-3-amino-3-aryl-2-hydroxypropanoates with high syn-selectivity and diastereoselectivit

Efficient and Practical Asymmetric Synthesis of the Taxol C-13 Side Chain, N-Benzoyl-(2R,3S)-3-phenylisoserine, and Its Analogues via Chiral 3-Hydroxy-4-aryl-β-lactams through Chiral Ester Enolate-Imine Cyclocondensation

A highly efficient chiral ester enolate-imine condensation giving 3-hydroxy-4-aryl-β-lactams with >96percent ee is successfully applied to the asymmetric synthesis of the enantiomerically pure taxol C-13 side chain, N-benzoyl-(2R,3S)-3-phenylisoserine, and its analogues.