13225-85-9

Basic information

• Product Name: 2-Pyridinecarbothioamide, N-(4-methoxyphenyl)-
• CAS NO: 13225-85-9
• Molecular Formula: C13H12N2OS
• Molecular Weight: 244.317
• Mol File: 13225-85-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-Pyridinecarbothioamide, N-(4-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyridinecarbothioamide, N-(4-methoxyphenyl)-(13225-85-9)
• EPA Substance Registry System: 2-Pyridinecarbothioamide, N-(4-methoxyphenyl)-(13225-85-9)

Safety Data

• Hazardous Substances Data: 13225-85-9(Hazardous Substances Data)

Upstream product

• 109-06-8 α-picoline 
• 104-94-9 4-methoxy-aniline 
• 100-17-4 para-methoxynitrobenzene 

Downstream Products

• 1206692-24-1 (NC₅H₄C(S)NC₆H₄OCH₃)AuCl₂ 

Relevant articles and documents

Synthesis and pharmacological activities of some mononuclear Ru(II) complexes

A series of mononuclear Ru(II) complexes of the type [Ru(M) 2(U)]2+, where M=2,2′-bipyridine/1,10-phenanthroline and U=tpl (Ru1), 4-Cl-tpl (Ru2), 4-CH3-tpl (Ru3), 4-CH 3O-tpl (Ru4), and 4-NO2-tpl (Ru5), -pai (Ru6), where tpl = thiopicolinanilide and pai = 2-phenyl-azo-imidazole, have been prepared and characterized by IR, UV-Vis, 1H NMR, 13C-NMR, FAB-Mass spectrophotometer, and elemental analysis. The complexes display metal-ligand charge transfer (MLCT) transitions in the visible region. The title complexes were subjected to in vivo anticancer activity tests against a transplantable murine tumor cell line, Ehrlich's ascitic carcinoma (EAC) and in vitro antibacterial activity against Gram positive and Gram negative microorganisms. Ru1-Ru6 were found to increase the life span of the tumor hosts by 19-52%, and decreased tumor volume and viable ascitic cell count. The results of the present study clearly demonstrated the tumor inhibitory activity of the ruthenium chelates against transplantable murine tumor cell line. The treatment with ruthenium complexes could be secondary to tumor regression or due to the action of the compounds itself. The significant antibacterial activity was observed for Ru1-Ru4 against microorganisms like Vibrio cholera 865, Staphylococcus aureus 6571, and Shigella flexneri as compared to that of standard drug chloramphenical. Ru5 showed moderate activity against S. aureus 8530. However, all the complexes fail to show significant antibacterial activity against V. cholera 14033 and Shigella sonnai.

Extractive Photometric Determination of Copper(II) and Stepwise Formation Constants of its Complexex with N-(4-Methoxy-phenyl)- and N-(4-Methyl-phenyl)-α-Thiopicolinamide

N-(4-Methoxy-phenyl)- and N-(4-methyl-phenyl)-α-thiopicolinamide forms brown complexes with copper(II) in the pH range 5.0-8.0 and 4.0-10.0, respectively.The chloroform extracts of the complexes have the absorption maxima at 440 and 430 nm and obey Beer's