13264-88-5Relevant articles and documents
METHOD FOR PRODUCING OPTICALLY ACTIVE 2-METHYLPIPERAZINE
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Paragraph 0064, (2017/01/26)
PROBLEM TO BE SOLVED: To provide a method capable of industrially obtaining an optically active 2-methylpiperazine which is easy in handling and has good properties, instead of the isolation method of an optically active 2-methylpiperazine by conventional distillation. SOLUTION: There is provided a method for producing an optically active 2-methylpiperazine by adding a solvent to a solution of an optically active 2-methylpiperazine, followed by solvent substitution and crystallization to obtain crystals of the optically active 2-methylpiperazine. SELECTED DRAWING: None COPYRIGHT: (C)2016,JPOandINPIT
The Absolute Configurations of (+)- and (-)-2-Methylpiperazines and their N-Methyl Derivatives.
Armarego, Wilfred L. F.,Schou, Henning,Waring, Paul
, p. 1951 - 1966 (2007/10/02)
S(-)-2-Methylpiperazinium dichloride was prepared by reduction of S(-)-3-methyl-2,5-dioxopiperazine (from glycyl-S-alanine) which established its absolute configuration.This dichloride and its enantiomer, R(+)-2-methylpiperazinium dichloride, were obtained in less optically pure forms by recrystallization of the diastereomeric RS-2-methylpiperazinium 2R,3R-di-O-benzoyltartrate salts followed by decomposition with a base.They were converted into S(+)- and R(-)-1,2,4-trimethylpiperazinium dichloride, S(+)- and R(-)-1,2,4,4-tetramethylpiperazinium iodide and S(+)- and R(-)-1,1,2,4,4-pentamethylpiperazinium diiodide.