132712-71-1Relevant articles and documents
Meglumine catalyzed one pot synthesis of new fluorescent 2-amino-4-pyrazolyl-6-aryldiazenyl-4H-chromene-3-carbonitriles
Korade, Suyog N.,Mhaldar, Pradeep M.,Kulkarni, Prafulladatta P.,Rashinkar, Gajanan S.,Pore, Dattaprasad M.
, p. 2336 - 2348 (2021/06/14)
Meglumine, a biodegradable basic organo-catalyst has been efficiently explored for the one-pot synthesis of new fluorescent 2-amino-4-(5-hydroxy-3-methyl-1H-pyrazol-4-yl)-6-aryldiazenyl-4H-chromene-3-carbonitriles in an aqueous medium at room temperature. The synthesized compounds were found highly fluorescent when screened for photoluminescence properties. The planar structure equipped with substituted aryldiazenyl group led to the extension of conjugation that facilitated fluorescence emission in the visible region with a large stokes shift of 290–294 nm. The novelty of work is a synthesis of highly conjugated molecular assembly, high yield in shorter reaction time, energy efficiency, atom economy, utilization of water as a universal green solvent and meglumine as an eco-benign organo-catalyst.
“On-water” one-pot four-component synthesis of novel 1H-furo[2,3-c]pyrazole-4-amine derivatives
Noruzian, Fatemeh,Olyaei, Abolfazl,Hajinasiri, Rahimeh
, p. 4383 - 4394 (2019/05/01)
A catalyst-free, simple and green protocol has been accomplished for the synthesis of novel 1H-furo[2,3-c]pyrazole-4-amines in a one-pot four-component domino reaction involving hydrazines, ethyl acetoacetate, aromatic amines and phenylglyoxal monohydrate in water. The protocol presented herein describes in situ generated pyrazolone as intermediate reactants with phenylglyoxal monohydrate in a Knoevenagel condensation followed by a Michael addition of amine, intramolecular cyclization, dehydration and the resulting to the title compound. It was observed that in this protocol bis(pyrazole-5-ols) are formed with amines bearing strong electron withdrawing groups under similar reaction conditions instead of the expected products. The reaction merits the use of water as solvent, no additive catalyst, easy workup, easy purification of products by non-chromatography and provides high yield of products with good purity.
Method for preparing pyridinyl-pyrazole compound
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Paragraph 0018; 0019; 0020, (2018/06/16)
The invention discloses a method for preparing a pyridinyl-pyrazole compound of 1-(2-aminopyridine-4-yl)-3-methyl-1H-pyrazole-5-ol. Ethyl acetoacetate is adopted a starting raw material, and the target product is obtained through cyclization, condensation and reduction. The compound is an important pharmaceutical intermediate.