185023-34-1

Basic information

• Product Name: ethyl 6-methyl-2-thioxo-4-(p-tolyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate
• Synonyms: ethyl 6-methyl-2-thioxo-4-(p-tolyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate
• CAS NO: 185023-34-1
• Molecular Formula: C₁₅H₁₈N₂O₂S
• Molecular Weight: 290.38062
• Mol File: 185023-34-1.mol
• Article Data: 106

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ethyl 6-methyl-2-thioxo-4-(p-tolyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 6-methyl-2-thioxo-4-(p-tolyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate(185023-34-1)
• EPA Substance Registry System: ethyl 6-methyl-2-thioxo-4-(p-tolyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate(185023-34-1)

Safety Data

• Hazardous Substances Data: 185023-34-1(Hazardous Substances Data)

Upstream product

• 104-87-0 4-methyl-benzaldehyde 
• 141-97-9 ethyl acetoacetate 
• 17356-08-0 thiourea 
• 2929-93-3 p-tolylmethylenediacetate 
• 1147550-11-5 ammonium thiocyanate 
• 589-18-4 4-Methylbenzyl alcohol 

Downstream Products

• 635292-04-5 ethyl 3-amino-5-(4-methylphenyl)-2-cyano-7-methyl-5H-thiazolo[a-2,3]pyrimidine-6-carboxylate 
• 324072-09-5 ethyl 5-(4-methylphenyl)-7-methyl-2-(4-chlorophenyl)methylene-3-oxo-2,3-dihydro-5H-thiazolo[a-2,3]pyrimidine-6-carboxylate 
• 847062-13-9 ethyl 6-methyl-2-(methylthio)-4-p-tolyl-1,4-dihydropyrimidine-5-carboxylate 
• 347322-42-3 5-(4-methylphenyl)-7-methyl-3-oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid ethyl ester 
• 1034918-27-8 6-ethoxycarbonyl-7-methyl-5-(4-methylphenyl)-5H-thiazolo[3,2-a]pyrimidine 

Relevant articles and documents

Supramolecular synthesis of 3,4-dihydropyrimidine-2(1H)-one/thiones under neat conditions

An efficient solvent free method for the synthesis of various 3,4-dihydropyrimidin-2(1H)-one/thiones in excellent yields using sulfonated β-cyclodextrine as recyclable catalyst is described. Sulfonated β-cyclodextrine was found to be efficient, recyclable

Microwave-assisted synthesis of dihydropyrimidin-2(1H)-ones using graphite supported lanthanum chloride as a mild and efficient catalyst

Graphite supported lanthanum chloride efficiently catalyzes the three-component coupling of β-ketoesters, aldehydes and urea/thiourea to afford corresponding dihydropyrimidinones in good yields under microwave irradiation.

Poly(N-vinyl-2-pyrrolidone)-supported ferric chloride: An effective reusable heterogeneous catalyst for one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones via three-component Biginelli reaction

An environmentally benign three-component Biginelli protocol for the one-pot synthesis of substituted 3,4-dihydropyrimidin-2(1H)-ones/thiones using an accessible, nontoxic, easy to handle, and recoverable macromolecular Lewis acidic catalyst is developed.

Green synthesis, structural analysis and anticancer activity of dihydropyrimidinone derivatives

In this study, for the first time, we have used Citrus macroptera juice to synthesize dihydropyrimidine (DHPM) derivatives via the Biginelli reaction, which showed better yield, shorter reaction time, and did not require an organic solvent for the reactio