13290-31-8

Basic information

• Product Name: (2-bromoethyl)(4-chlorophenyl)sulfane
• Synonyms: (2-bromoethyl)(4-chlorophenyl)sulfane
• CAS NO: 13290-31-8
• Molecular Weight: 251.575
• Mol File: 13290-31-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (2-bromoethyl)(4-chlorophenyl)sulfane(CAS DataBase Reference)
• NIST Chemistry Reference: (2-bromoethyl)(4-chlorophenyl)sulfane(13290-31-8)
• EPA Substance Registry System: (2-bromoethyl)(4-chlorophenyl)sulfane(13290-31-8)

Safety Data

• Hazardous Substances Data: 13290-31-8(Hazardous Substances Data)

Upstream product

• 106-93-4 ethylene dibromide 
• 106-54-7 p-Chlorothiophenol 

Downstream Products

• 38265-72-4 Dithiophosphoric acid S-[2-(4-chloro-phenylsulfanyl)-ethyl] ester O-ethyl ester S'-(2-methoxy-ethyl) ester 
• 38265-73-5 Dithiophosphoric acid S-[2-(4-chloro-phenylsulfanyl)-ethyl] ester S'-(2-ethoxy-ethyl) ester O-ethyl ester 
• 1453066-53-9 9-O-[2-(p-chloro)thiophenyl]ethyl-berberine bromide 
• 5535-51-3 p-chlorophenyl vinyl sulfone 
• 16411-16-8 p-chlorophenyl vinyl sulfide 
• 5409-87-0 1,2-bis((4-chlorophenyl)thio)ethane 
• 55247-59-1 Benzyl-[2-(4-chloro-phenylsulfanyl)-ethyl]-amine 

Relevant articles and documents

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PYRIMIDINE OR PYRIDOPYRIDONE COMPOUND AND APPLICATION THEREOF

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Synthesis and biological evaluation of berberine-thiophenyl hybrids as multi-functional agents: Inhibition of acetylcholinesterase, butyrylcholinesterase, and Aβ aggregation and antioxidant activity

A series of berberine-thiophenyl hybrids were designed, synthesised, and evaluated as inhibitors of acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) and β-amyloid (Aβ) aggregation and as antioxidants. Among these hybrids, compounds 4f and 4i, berberine linked with o-methylthiophenyl and o-chlorothiophenyl by a 2-carbon spacer, were observed to be potent inhibitors of AChE, with IC50 values of 0.077 and 0.042 μM, respectively. Of the tested compounds, 4i was also the most potent inhibitor of BuChE, with an IC50 value of 0.662 μM. Kinetic studies and molecular modelling simulations of the AChE-inhibitor complex indicated that a mixed-competitive binding mode existed for these berberine derivatives. The biological studies also demonstrated that these hybrids displayed interesting activities, including Aβ aggregation inhibition and antioxidant properties.