133101-42-5

Basic information

• Product Name: 1-<2-(methoxymethoxy)phenyl>-1-propanone
• Synonyms: 1-<2-(methoxymethoxy)phenyl>-1-propanone
• CAS NO: 133101-42-5
• Molecular Weight: 194.23
• Mol File: 133101-42-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-<2-(methoxymethoxy)phenyl>-1-propanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-<2-(methoxymethoxy)phenyl>-1-propanone(133101-42-5)
• EPA Substance Registry System: 1-<2-(methoxymethoxy)phenyl>-1-propanone(133101-42-5)

Safety Data

• Hazardous Substances Data: 133101-42-5(Hazardous Substances Data)

Upstream product

• 610-99-1 1-(2-Hydroxy-phenyl)-propan-1-on 
• 107-30-2 chloromethyl methyl ether 

Downstream Products

• 925923-78-0 2-amino-6-[2-(methoxymethoxy)phenyl]-5-methyl-4-(3-nitrophenyl)pyridine-3-carbonitrile 
• 133101-62-9 cis-(RS,SR)-γ-hydroxy-γ-<2-(methoxymethoxy)phenyl>-β-methylbutanoic acid lactone 
• 133101-62-9 trans-(RR,SS)-γ-hydroxy-γ-<2-(methoxymethoxy)phenyl>-β-methylbutanoic acid lactone 
• 133101-52-7 γ-<2-(methoxymethoxy)phenyl>-β-methyl-γ-oxobutanoic acid 

Relevant articles and documents

Synthesis and structure-activity relationships of 2-acylamino-4,6-diphenylpyridine derivatives as novel antagonists of GPR54

GPR54 is a G protein-coupled receptor (GPCR) which was formerly an orphan receptor. Recent functional study of GPR54 revealed that the receptor has an essential role to modulate sex-hormones including GnRH. Though antagonists of GPR54 are expected to be novel drugs for sex-hormone dependent diseases such as prostate cancer or endometriosis, small molecule GPR54 antagonists have not been reported. We have synthesized a series of 2-acylamino-4,6-diphenylpyridines to identify potent GPR54 antagonists. Detailed structure-activity relationship studies led to compound 9l with an IC50 value of 3.7 nM in a GPR54 binding assay, and apparent antagonistic activity in a cellular functional assay.