1333119-98-4Relevant articles and documents
Copper-Catalyzed coupling of oxime acetates with aldehydes: A new strategy for synthesis of pyridines
Ren, Zhi-Hui,Zhang, Zhi-Yuan,Yang, Bing-Qin,Wang, Yao-Yu,Guan, Zheng-Hui
, p. 5394 - 5397 (2011)
Copper-catalyzed coupling of oxime acetates with aldehydes offers a new strategy for the synthesis of highly substituted pyridines. This novel method tolerates a wide range of functionality and allows for rapid elaboration of the oxime acetates into a variety of substituted pyridines.
Iron-Catalyzed Cyclization of Ketoxime Carboxylates and Tertiary Anilines for the Synthesis of Pyridines
Zhao, Mi-Na,Ren, Zhi-Hui,Yu, Le,Wang, Yao-Yu,Guan, Zheng-Hui
supporting information, p. 1194 - 1197 (2016/03/15)
A novel and efficient iron-catalyzed cyclization of ketoxime carboxylates and N,N-dialkylanilines for the modular synthesis of diverse pyridines was developed. The reaction was initiated by Fe-catalyzed N-O bond cleavage of ketoxime carboxylates in the presence of tertiary anilines. The methylene carbon on N,N-dialkylanilines functioned as a source of one-carbon synthon in the reaction. The reaction used readily available starting materials, tolerated various functional groups, and afforded 2,4-disubstituted and 2,4,6-trisubstituted pyridines in good to high yields under mild conditions.