1333120-03-8

Basic information

• Product Name: 2,6-bis(2,5-dimethylphenyl)-4-phenylpyridine
• Synonyms: 2,6-bis(2,5-dimethylphenyl)-4-phenylpyridine
• CAS NO: 1333120-03-8
• Molecular Weight: 363.502
• Mol File: 1333120-03-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2,6-bis(2,5-dimethylphenyl)-4-phenylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-bis(2,5-dimethylphenyl)-4-phenylpyridine(1333120-03-8)
• EPA Substance Registry System: 2,6-bis(2,5-dimethylphenyl)-4-phenylpyridine(1333120-03-8)

Safety Data

• Hazardous Substances Data: 1333120-03-8(Hazardous Substances Data)

Upstream product

• 939-23-1 p-phenylpyridine 
• 553-94-6 4-bromo-m-xylene 
• 1333119-98-4 C₁₂H₁₅NO₂ 
• 100-52-7 benzaldehyde 
• 88166-78-3 1-(2,5-dimethylphenyl)ethanone oxime 

Relevant articles and documents

Direct C-H Functionalization of Pyridine via a Transient Activator Strategy: Synthesis of 2,6-Diarylpyridines

A Pd-catalyzed highly selective direct diarylation of pyridines has been developed using a transient activator strategy. Both (MeO)2SO2 and Cu2O are required for this transformation. The in situ generated N-methylpyridinium salt can be arylated at both 2- and 6-positions under the cooperative Pd/Cu catalysis. A subsequent N-demethylation then gives the 2,6-diarylpyridines. This protocol provides a novel synthetic route for the symmetric 2,6-diarylpyridines.

Synthesis of symmetrical pyridines by iron-catalyzed cyclization of ketoxime acetates and aldehydes

A novel and facile iron-catalyzed cyclization of ketoxime acetates and aldehydes for the green synthesis of substituted pyridines has been developed. In the presence of a FeCl3 catalyst, this reaction exhibited a good functional group tolerance to produce 2,4,6-triarylsubstituted symmetrical pyridines in high yields in the absence of any additive. A gram-scale reaction sequence was performed to demonstrate the scaled-up applicability of this synthetic method.