1333257-57-0Relevant articles and documents
Inhibitors of the herbicidal target IspD: Allosteric site binding
Witschel, Matthias C.,Hoeffken, H. Wolfgang,Seet, Michael,Parra, Liliana,Mietzner, Thomas,Thater, Frank,Niggeweg, Ricarda,Roehl, Franz,Illarionov, Boris,Rohdich, Felix,Kaiser, Johannes,Fischer, Markus,Bacher, Adelbert,Diederich, Francois
supporting information; experimental part, p. 7931 - 7935 (2011/10/09)
The pick of the pockets: The first inhibitors for IspD, an enzyme from the non-mevalonate pathway of isoprenoid biosynthesis, are described. High-throughput-screening revealed a hit with an IC50 value of 140 nM. Co-crystal structure analyses of the binding mode in the newly formed allosteric pocket (see structure, red ball: water O atom), lead to the synthesis of a set of 17 derivatives which were tested to optimize the herbicidal activity.
