1333492-61-7

Basic information

• Product Name: 2-phenyl-4-(3-(pyridin-2-yl)-1-trityl-1H-pyrazol-4-yl)pyridine
• Synonyms: 2-phenyl-4-(3-(pyridin-2-yl)-1-trityl-1H-pyrazol-4-yl)pyridine
• CAS NO: 1333492-61-7
• Molecular Weight: 540.667
• Mol File: 1333492-61-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-phenyl-4-(3-(pyridin-2-yl)-1-trityl-1H-pyrazol-4-yl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-phenyl-4-(3-(pyridin-2-yl)-1-trityl-1H-pyrazol-4-yl)pyridine(1333492-61-7)
• EPA Substance Registry System: 2-phenyl-4-(3-(pyridin-2-yl)-1-trityl-1H-pyrazol-4-yl)pyridine(1333492-61-7)

Safety Data

• Hazardous Substances Data: 1333492-61-7(Hazardous Substances Data)

Upstream product

• 446852-65-9 2-(2-bromopyridin-4-yl)-1-(pyridin-2-yl)ethan-1-one 
• 446880-81-5 2-bromo-4-(3-(pyridine-2-yl)-1H-pyrazol-4-yl)pyridine 
• 446880-83-7 2-bromo-4-(3-(pyridin-2-yl)-1-trityl-1H-pyrazol-4-yl)pyridine 
• 98-80-6 phenylboronic acid 
• 4926-28-7 2-Bromo-4-picoline 
• 2524-52-9 ethyl-2-picolinate 

Downstream Products

• 452342-37-9 2-phenyl-4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridine 

Relevant articles and documents

2-Phenyl and 2-heterocyclic-4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridines as inhibitors of TGF-β1 and activin A signalling

Novel inhibitors of TGF-β1 and activin A signalling based on a 2-aryl-4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridine pharmacophore have been synthesised. Compounds containing phenyl or aromatic nitrogen heterocycle substituents inhibited both types of signalling with HEK-293T cells in culture, with a selectivity preference for TGF-β1. Synthetic compounds containing pyridin-3-yl, pyrazol-4-yl, pyrazol-1-yl or 1H-imidazoyl-1-yl substituents exhibited structural and functional attributes suitable for further investigation related to the development of more potent TGF-β inhibitors.