1334294-95-9

Basic information

• Product Name: 3-hydroxy-2-propyl-3-p-tolylisoindolin-1-one
• Synonyms: 3-hydroxy-2-propyl-3-p-tolylisoindolin-1-one
• CAS NO: 1334294-95-9
• Molecular Weight: 281.354
• Mol File: 1334294-95-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-hydroxy-2-propyl-3-p-tolylisoindolin-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-hydroxy-2-propyl-3-p-tolylisoindolin-1-one(1334294-95-9)
• EPA Substance Registry System: 3-hydroxy-2-propyl-3-p-tolylisoindolin-1-one(1334294-95-9)

Safety Data

• Hazardous Substances Data: 1334294-95-9(Hazardous Substances Data)

Upstream product

• 1074-82-4 potassium phtalimide 
• 33125-70-1 3-hydroxy-2-propyl-2,3-dihydroisoindol-1-one 
• 5323-50-2 N-propylphthalimide 
• 1334294-88-0 2-propyl-3-p-tolylisoindolin-1-one 

Relevant articles and documents

A direct arylation-oxidation route to 3-arylisoindolinone inhibitors of MDM2-p53 interaction

A route to the MDM2-p53 inhibitor isoindolinone pharmacophore from a pre-formed phthalimide is detailed. The route involves treatment of 3-hydroxy-2-(n-propyl)isoindolinone with a substituted benzene in the presence of triflic acid. The resulting 3-aryl-2-(n-propyl)isoindolinones are then oxidized to the corresponding 3-hydroxy-3-aryl-2-(n-propyl) isoindolinones by treatment with 2,2'-bipyridinium chlorochromate. The benzylic oxidation represents a rather rare oxochromium (VI)-mediated reaction in which a selective C-H to C-OH transformation occurs.