1334528-90-3

Basic information

• Product Name: (E)-3-(3,4-difluorophenyl)acrylaldehyde
• Synonyms: (E)-3-(3,4-difluorophenyl)acrylaldehyde
• CAS NO: 1334528-90-3
• Molecular Weight: 168.143
• Mol File: 1334528-90-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (E)-3-(3,4-difluorophenyl)acrylaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-3-(3,4-difluorophenyl)acrylaldehyde(1334528-90-3)
• EPA Substance Registry System: (E)-3-(3,4-difluorophenyl)acrylaldehyde(1334528-90-3)

Safety Data

• Hazardous Substances Data: 1334528-90-3(Hazardous Substances Data)

Upstream product

• 34036-07-2 3,4 difluorobenzaldehyde 
• 75-07-0 acetaldehyde 
• 112897-97-9 (E)-3-(3,4-difluorophenyl)acrylic acid 
• 1421708-29-3 (E)-3-(3,4-difluorophenyl)-N-methoxy-N-methyl-prop-2-enamide 
• 21204-67-1 methyl (triphenylphosphoranylidene)acetate 

Downstream Products

• 1334529-02-0 (R)-tert-butyl 4-(3,4-difluorophenyl)-2-methyl-6-oxo-1,4,5,6-tetrahydropyridine-3-carboxylate 
• 1419701-11-3 (R)-9-(3,4-difluorophenyl)-10-propyl-8,9-dihydro-7H-benzo[4,5]isothiazolo[2,3-a]pyridin-7-one 5,5-dioxide 
• 220352-36-3 trans-(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid 

Relevant articles and documents

Ticagrelor intermediate, and preparation method thereof

The invention belongs to the technical field of drug synthesis, and relates to a ticagrelor intermediate, and a preparation method thereof. The ticagrelor intermediate can be prepared conveniently via following steps: (E)-3-(3,4-difluorophenyl) propenal a

Enantioselective synthesis of dihydropyridinones via NHC-Catalyzed Aza-Claisen reaction

N-Heterocyclic carbene catalyzed aza-Claisen annulations of enals or their α-hydroxyenone surrogates with vinylogous amides afford dihydropyridinones. The reaction proceeds with a broad range of substrates, and no nitrogen protecting group is required.