220352-36-3

Basic information

• Product Name: (1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid
• Synonyms: (1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid;(1R,2R)-2-(3,4-difluorophenyl)cyclopropane-1-carboxylic acid;Ticagrelor Related Compound 28
• CAS NO: 220352-36-3
• Molecular Formula: C₁₀H₈F₂O₂
• Molecular Weight: 198.1661264
• EINECS: 1533716-785-6
• Mol File: 220352-36-3.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 308.1±42.0 °C(Predicted)
• Appearance: /
• Density: 1.435±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Sparingly)
• PKA: 4.53±0.10(Predicted)
• CAS DataBase Reference: (1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid(220352-36-3)
• EPA Substance Registry System: (1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid(220352-36-3)

Safety Data

• Hazardous Substances Data: 220352-36-3(Hazardous Substances Data)

Usage

Description

(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid is an organic compound characterized by its cyclopropane ring and difluorophenyl group. It is a chiral molecule with specific stereochemistry at the first and second carbon atoms, denoted as (1R,2R). (1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid serves as a key intermediate in the synthesis of various pharmaceuticals due to its unique structural features and reactivity.

Uses

Used in Pharmaceutical Industry:
(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid is used as an intermediate for the preparation of AZD6140, an orally active reversible P2Y12 receptor antagonist. This application is significant for the prevention of thrombosis, a condition characterized by the formation of blood clots within the circulatory system, which can lead to serious health complications such as heart attacks and strokes.
Additionally, (1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid is used in the synthesis of triazolopyrimidine derivatives, which act as P2T receptor antagonists. These derivatives have potential applications in the treatment of various diseases and disorders, highlighting the versatility of this intermediate in the development of novel therapeutic agents.

Upstream product

• 1006376-61-9 (1R,2R)-2-(3,4-difluorophenyl)-1-cyclopropanecarboxylic acid ethyl ester 
• 112897-97-9 (E)-3-(3,4-difluorophenyl)acrylic acid 
• 1043546-64-0 3,4-difluorocinnamoyl chloride 
• 34036-07-2 3,4 difluorobenzaldehyde 
• 405-03-8 1-(3,4-difluorophenyl)ethene 
• 1006376-60-8 (1S)-2-chloro-1-(3,4-difluorophenyl)-1-ethanol 
• 1006376-63-1 (S)-2-(3,4-difluorophenyl)ethylene oxide 
• 367-11-3 ortho-difluorobenzene 
• 51336-95-9 2-chloro-1-(3,4-difluorophenyl)ethan-1-one 
• 1450916-28-5 (1R,2R)-2-(3,4-difluorophenyl)cyclopropane carbonitrile 
• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 1334528-90-3 (E)-3-(3,4-difluorophenyl)acrylaldehyde 
• 692288-05-4 C₄H₅IO₂ 
• 168267-41-2 (3,4-difluorophenyl)boronic acid 

Downstream Products

• 376608-70-7 trans-(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarbonyl chloride 
• 378236-67-0 (1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarbonyl azide 
• 1006614-49-8 (1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine 
• 274693-26-4 [3aR-[3aα,4α,6α,(1R,2S),6aα]]-2-[6-[[[7-(2-(3,4-difluorophenyl)cyclopropyl)]amino-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]tetrahydro-2,2-dimethyl-4H-cyclopenteno-1,3-dioxolan-4-yl]oxy]ethanol 
• 274693-27-5 ticagrelor 
• 1353964-60-9 trans-(1R,2R)-2-(3,4-difluorophenyl)-N-hydroxycyclopropanecarboxamide 
• 1353964-63-2 trans-(1R,2R)-N-(acetyloxy)-2-(3,4-difluorophenyl)cyclopropane carboxamide 
• 1353964-70-1 trans-(1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamine (S)-ketopinate 
• 1353964-72-3 trans-(1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamine (D)-camphorsulfonate 
• 1353964-85-8 trans-(1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamine (R)-(-)-α-methoxyphenyl acetate 
• 220347-05-7 AR-C₁₂₄₉₁₀XX 
• 274693-49-1 (3aR,4S,6R,6aS)-6-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-ol 
• 1006376-62-0 (1R,2R)-trans-2(3,4-difluorophenyl)cyclopropyl carboxamide 

Relevant articles and documents

Preparation method of phenyl-containing compound

The present invention discloses a method for preparing an phenyl-containing compound. The present invention provides a method for preparing a compound shown in formula I, comprising the following steps: in the presence of formamide or acetamide, in the pr

Preparation method of ticagrelor key intermediate

The invention belongs to the technical field of medicines, and particularly relates to a preparation method of a ticagrelor key intermediate, and the method is used for preparing the ticagrelor intermediate, has the advantages of short reaction steps, mild reaction conditions and higher yield than the existing preparation method, is economical and effective, and is suitable for large-scale industrial production.

Ticagrelor key intermediate and preparation method thereof

The invention discloses a ticagrelor key intermediate 1-TK-acid and a preparation method of the ticagrelor key intermediate 1-TK-acid. The ticagrelor key intermediate has a structure shown in a formula (D) which is shown in the description. The method comprises the following steps of (1) preparing 2-chloro-1-(3,4-difluorophenyl)ethanone; (2) preparing a methylbenzene solution of 2-chloro-1-S-(3,4-difluorophenyl)ethyl alcohol; (3) preparing the ticagrelor key intermediate 1-TK-acid. The ticagrelor key intermediate 1-TK-acid has the advantages that the technology is matured and stable, the product quality is stable, the production technology is safe and reliable, and the ticagrelor key intermediate 1-TK-acid is suitable for industrialized production.